Partial chemical reprogramming in mouse fibroblasts using a compound cocktail can reduce biological age. Multi-omics analysis shows significant improvements in mitochondrial function, gene expression, and a reduction in ageing-related metabolites, indicating potential for in vivo age reversal.
March 2024 – eLife
Key takeaways
- Reduction of biological age: Partial chemical reprogramming, using specific cocktails of compounds, can shift cells to a younger biological state. This process involves resetting certain cellular markers of ageing, thereby potentially delaying the onset of age-related diseases and extending cellular healthspan
- Improvement in mitochondrial function: The reprogramming process significantly enhances mitochondrial function. It increases mitochondrial oxidative phosphorylation activity, which is crucial for energy production in cells. Enhanced mitochondrial function is linked to improved cellular energy metabolism and reduced signs of ageing
- Reversal of age-associated gene expression: Gene expression patterns that typically signify ageing are reversed through partial chemical reprogramming. This means that cells begin to express genes in a manner similar to much younger cells, contributing to improved cellular function and resilience
- Reduction in ageing-related metabolites: The levels of metabolites that accumulate as cells age are significantly reduced through reprogramming. These metabolites often contribute to cellular damage and dysfunction. By lowering their levels, the reprogramming process helps maintain healthier cellular environments, promoting longevity and potentially extending the lifespan of organisms
Read the article at: Mitchell, Wayne, et al. “Multi-Omics Characterization of Partial Chemical Reprogramming Reveals Evidence of Cell Rejuvenation.” eLife, vol. 12, 2023, DOI:10.7554/eLife.90579.