DIM’s impact on oral health and longevity

Sep 17, 2023

3,3′-Diindolylmethane (DIM), a natural compound, shows remarkable efficacy in breaking down the biofilm of Streptococcus mutans, which is implicated in dental caries. DIM reduces biofilm formation by 92% and decreases the production of substances that bacteria use to shield themselves, potentially offering a new approach to improving dental health and contributing to longevity.

June 2023 – Antibiotics


Key takeaways


  • Biofilm disruption: DIM effectively interferes with the development of Streptococcus mutans biofilms, which are complex bacterial communities responsible for tooth decay, a common health issue that can affect quality of life as we age
  • Significant reduction in biofilm formation: The application of DIM results in a dramatic 92% decrease in the formation of these biofilms, suggesting a strong potential for DIM to be used as a preventive measure in oral health care, which is crucial for maintaining overall health and well-being in the elderly
  • Weakening of bacterial defenses: By diminishing the production of extracellular polymeric substances, DIM weakens the structural integrity of the biofilm, making it easier to remove and less capable of causing long-term dental damage, which is particularly beneficial for ageing populations who may face challenges with dental care
  • Enhanced durability in acidic conditions: The ability of DIM to compromise the biofilm’s resilience in acidic environments, which are typical after consuming sugar-rich foods, points to its role in not just preventing dental caries but also in potentially maintaining the structural integrity of teeth, a significant concern as we age


Read the article at: Baruch, Yifat, et al. “3,3′-Diindolylmethane (DIM): A Potential Therapeutic Agent against Cariogenic Streptococcus Mutans Biofilm.Antibiotics, vol. 12, no. 6, June 2023, p. 1017. Crossref,