Integrated systems analysis of mouse liver data revealed consistent patterns in fatty acid oxidation across various lifespan-extending interventions. These interventions highlighted overarching biological processes in ageing and longevity, suggesting the potential to improve health and extend lifespan by targeting these processes.
- Unified impact on molecular biology: Diverse lifespan-extending interventions share a common influence on the regulation of several fundamental molecular processes. This includes tightening the control of key elements in molecular biology, such as fatty acid oxidation, immune response mechanisms, and stress response pathways
- Fatty acid oxidation as a key player: Fatty acid oxidation emerges as a central player affected by lifespan-extending interventions, regardless of type. The study’s findings suggest that the metabolic processes related to fatty acid oxidation are not mere bystanders but crucial determinants of lifespan. This metabolic pathway appears to be finely tuned and tightly regulated by these interventions, implying its significance in governing the overall ageing process
The consistent patterns observed in the study indicate that by targeting specific biological processes, there’s potential to not only extend lifespan but also improve overall health.
Reference: Watanabe, K., Wilmanski, T., Baloni, P. et al. Lifespan-extending interventions induce consistent patterns of fatty acid oxidation in mouse livers. Commun Biol 6, 768 (2023). https://doi.org/10.1038/s42003-023-05128-y