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Fisetin supplementation for cellular senescence reduction

Dec 19, 2023

Fisetin, a natural compound, has been found to improve arterial function in old mice by reducing cellular senescence. This was achieved through intermittent dosing, which led to enhanced endothelial function and decreased arterial stiffness. The improvements were linked to increased nitric oxide availability and reduced oxidative stress, indicating fisetin’s potential as a therapy for age-related arterial dysfunction.

December 2023 – Aging Cell


Key takeaways


  • Fisetin’s senolytic properties: Fisetin demonstrates a remarkable ability to target and reduce cellular senescence, a process where cells cease to divide and accumulate with age, contributing to age-related decline. By decreasing the number of senescent cells, fisetin addresses a fundamental aspect of the ageing process, potentially extending the healthspan of vascular systems
  • Improved arterial function in ageing: Regular, intermittent doses of fisetin have been shown to significantly enhance the function of arteries in older subjects. This includes improving the elasticity and flexibility of blood vessels, which are crucial for healthy blood flow and reducing the risk of cardiovascular diseases commonly associated with ageing
  • Enhanced nitric oxide bioavailability: Fisetin increases the bioavailability of nitric oxide, a molecule essential for vascular health. Nitric oxide helps in vasodilation, the process of widening blood vessels, which improves blood flow and reduces blood pressure. This mechanism is vital for maintaining cardiovascular health, especially in the elderly


The antioxidative and anti-inflammatory effects of fisetin suggest its potential role in preventing or mitigating age-related diseases, particularly those related to the cardiovascular system. By reducing oxidative stress and inflammation, fisetin could help in preserving the function of various organ systems, potentially leading to a healthier, longer life.


Read the article at: Mahoney, Sophia A., et al. “Intermittent Supplementation with Fisetin Improves Arterial Function in Old Mice by Decreasing Cellular Senescence.” Aging Cell, vol. no., 2023, doi:10.1111/acel.14060.