Hypothalamic neurons: Key to longer life?

Jan 19, 2024

DMHPpp1r17 neurons in the mouse hypothalamus play a crucial role in regulating ageing and lifespan. They influence physical activity and white adipose tissue function, impacting the ageing process. Modifying these neurons’ activity can alleviate age-related decline and potentially extend lifespan.

January 2024 – Cell Metabolism


Key takeaways


  • Hypothalamic neurons as ageing regulators: DMHPpp1r17 neurons, located in the mouse hypothalamus, are identified as significant regulators of ageing and lifespan. This suggests that the hypothalamus plays a more central role in ageing than previously understood
  • Influence on physical activity and fat tissue: These neurons exert control over physical activity levels and the functioning of white adipose tissue (WAT). Since both physical activity and healthy fat tissue functionality are crucial in ageing, this finding links brain function directly to these critical aspects of health in ageing
  • Potential for reversing age-related decline: Techniques like DMH-specific Prkg1 knockdown, which target these neurons, have been shown to mitigate age-associated decline in tissue function. This implies that manipulating the activity of these specific neurons could be a strategy to reverse or slow down some aspects of the ageing process
  • Lifespan extension through neuronal activation: The study demonstrates that activating DMHPpp1r17 neurons can lead to an extension of lifespan in mice. This highlights a promising area for future research and potential therapeutic interventions aimed at promoting longevity and combating age-related diseases


Read the article at: Tokizane, Kyohei, et al. “DMHPpp1r17 Neurons Regulate Aging and Lifespan in Mice through Hypothalamic-Adipose Inter-Tissue Communication.Cell Metabolism, 2024, ISSN 1550-4131,