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Inflammation and ageing: Genetic connections

Sep 20, 2023

Anti-ageing interventions appear to converge on a cellular level, consistently downregulating genes associated with inflammation and upregulating those involved in fatty acid metabolism. This dual action at the genetic expression level may be a key mechanism by which these interventions promote longevity and combat age-related decline.

September 2023 – GeroScience

 

Key takeaways

 

  • Reduced inflammation: Longevity-focused treatments consistently suppress genes that trigger inflammation, which is a known contributor to ageing and many chronic diseases. By controlling inflammation, these interventions may slow down the ageing process and reduce the risk of age-related health issues
  • Restored fatty acid metabolism: Ageing is often accompanied by a decline in the body’s ability to metabolise fatty acids, leading to metabolic imbalances. Geroprotective interventions help to reverse this decline, restoring fatty acid metabolism which is essential for maintaining cellular health and energy balance as we age
  • Common ageing pathway: The similar patterns of gene expression alteration across different anti-ageing treatments suggest that they may target a universal ageing pathway. This could mean that despite the variety of available interventions, they might be effective due to their impact on this shared pathway, offering a focal point for future ageing research

 

Read the article at: Landsberger, T., Amit, I. & Alon, U. Geroprotective interventions converge on gene expression programs of reduced inflammation and restored fatty acid metabolismGeroScience (2023). https://doi.org/10.1007/s11357-023-00915-1