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Neuronal mTORC1’s role in longevity

Sep 25, 2023

Inhibiting mTORC1 in C. elegans’ neurons extends lifespan without hindering growth and reproduction, offering a potential pathway to promote longevity while maintaining life quality.

September 2023 – PLOS Genetics


Key takeaways


  • Neuronal mTORC1 inhibition and lifespan extension: Targeting mTORC1, a complex involved in cell growth and metabolism, specifically within neurons, has been shown to increase the lifespan of organisms. This suggests that the nervous system plays a crucial role in controlling the ageing process
  • Preservation of growth and reproduction: Despite the extended lifespan, the inhibition of mTORC1 does not adversely affect an organism’s ability to grow or reproduce. This is particularly significant as it implies that it is possible to extend lifespan without sacrificing the fundamental biological processes necessary for species survival
  • Focused mTORC1 suppression as an anti-ageing strategy: The research indicates that precise and targeted suppression of mTORC1 in the nervous system could be a viable strategy for anti-ageing therapies. This targeted approach might help in avoiding the side effects that can arise from systemic inhibition of mTORC1
  • Separation of ageing and growth mechanisms: The findings support the idea that the biological pathways governing growth and ageing can be decoupled. This decoupling is promising for developing treatments that specifically address ageing and age-related diseases, potentially allowing individuals to enjoy longer periods of health and vitality


Read the article at: Han, Seung-Jae, et al. “Neuronal mTORC1 Inhibition Promotes Longevity Without Suppressing Anabolic Growth and Reproduction in C. elegans.PLOS Genetics, vol. 18, no. 3, Mar. 2022, doi:10.1371/journal.pgen.1010938.