Nutmeg compound extends lifespan of fruit flies

Jan 3, 2024

Nectandrin B, a compound derived from nutmeg, has been found to significantly extend the lifespan of fruit flies by up to 42.6%. This increase in lifespan is also associated with improvements in various age-related conditions, including locomotive and neurological deterioration, suggesting its potential as a therapeutic agent for longevity and age-related degeneration.

November 2023 – Aging


Key takeaways


  • Nectandrin B extends lifespan: The compound Nectandrin B, derived from the nutmeg tree, has demonstrated a remarkable ability to extend the lifespan of fruit flies. This significant increase, reaching up to 42.6%, suggests a profound impact on the biological processes governing ageing
  • Improvement in age-related symptoms: Beyond just extending life, Nectandrin B has shown efficacy in alleviating common age-related symptoms. This includes a notable improvement in locomotive functions, which often deteriorate with age, and effective management of body weight, a key factor in healthy ageing
  • Neurodegenerative and eye health benefits: The compound’s benefits extend to critical areas like neurodegenerative health and eye conditions. It has shown potential in reducing the progression of neurodegenerative diseases and in preserving eye health, both of which are major concerns in the ageing process


These promising results in fruit flies open up the possibility of Nectandrin B being a valuable therapeutic agent for human longevity. Its ability to tackle various facets of ageing, from physical deterioration to neurological health, positions it as a potential candidate for future research in human ageing and longevity enhancement.


Read the article at: Ahn, Ji-Seon, et al. “Nectandrin B Significantly Increases the Lifespan of Drosophila – Nectandrin B for Longevity.” Aging, vol. 15, no. 22, 2023, pp. 12749-12762, doi:10.18632/aging.205234.