Melbourne Functional Medicine logo

Protective effects of apigenin on brain health and cognitive function

Jan 14, 2024

Apigenin improves memory and learning in older mice by modulating immune and inflammation-related genes. It also reduces inflammation and cellular ageing in astrocytes, potentially protecting against age-related cognitive decline.

November 2023 – Mechanisms of Ageing and Development


Key findings


  • Apigenin enhances cognitive functions: Apigenin, found in certain plants, has been observed to significantly boost learning and memory in older mice, suggesting its potential role in enhancing cognitive abilities during ageing
  • Genetic influence: This compound impacts key genes involved in immune responses, inflammation, and neuronal function. Such genetic modulation is important for maintaining brain health and combating the detrimental effects of ageing
  • Reduction in neuroinflammation: Apigenin shows promise in reducing brain inflammation, which is a critical factor in the development of age-related cognitive disorders. By controlling inflammation, it could play a vital role in preserving mental acuity in older age
  • Impact on astrocytes: In aged astrocytes, which are crucial for supporting neurons, apigenin reduces signs of inflammation and cellular ageing. This suggests it could have a comprehensive protective effect against the overall process of brain ageing, contributing to longer cognitive health


Read the article at: Cavalier, Alyssa N., et al. “Protective effects of apigenin on the brain transcriptome with aging.” Mechanisms of Ageing and Development, vol. 217, 2024, doi: 10.1016/j.mad.2023.111889.