Reversing ageing in blood stem cells

Feb 1, 2024

Epigenetic changes in ageing hematopoietic stem cells are linked to hematologic disorders, highlighting the importance of DNA methylation and histone modifications.

December 2023 – Epigenomes


Key takeaways


  • Ageing in hematopoietic stem cells: The natural ageing process in hematopoietic stem cells leads to significant epigenetic alterations, which are central to the decline in blood health and function, impacting overall longevity and predisposition to ageing-related blood disorders
  • Role of DNA methylation and histone modifications: These specific epigenetic changes, including DNA methylation and histone modifications, are crucial in regulating gene expression within ageing stem cells, influencing the onset and progression of hematologic conditions linked to ageing
  • Contribution to hematologic disorders: The cumulative effect of these epigenetic modifications is a key factor in the development of age-related hematologic disorders, highlighting the importance of understanding these processes for early detection and prevention strategies


There is a growing interest in exploring epigenetic therapies as a means to reverse or mitigate the adverse effects of ageing on hematopoietic stem cells. These therapies hold promise for extending healthspan, improving longevity, and providing targeted treatments for ageing-associated hematologic diseases.


Read the article at: Guryanova, Olga A., et al. “Epigenetic Mechanisms in Hematologic Aging and Premalignant Conditions.” Epigenomes, vol. 7, no. 4, 2023, 32.