The link between moderate workouts and ageing well

Jul 16, 2023

Moderate exercise in mice results in metabolic and epigenetic alterations in macrophages, diminishing their inflammatory reactions. This activity enhances cellular oxygen use, decreases damaging compounds, and modifies DNA accessibility, providing insights into longevity and ageing.


Key takeaways: Moderate exercise induces trained immunity in macrophages


  • Moderate exercise benefits: Engaging in moderate exercise can lead to significant metabolic and epigenetic changes that can influence longevity. This suggests that consistent, moderate physical activity could be a key factor in promoting healthy ageing
  • Reduced inflammation: These exercises can decrease inflammatory responses in macrophages, cells crucial for immune function. Reduced inflammation can potentially decrease the risk of age-related diseases and improve overall health
  • Improved cellular function: Exercise enhances a cell’s ability to use oxygen efficiently, reducing the production of potentially harmful compounds. This efficient oxygen utilisation can lead to better cellular energy production and reduced oxidative stress, both important for longevity
  • DNA accessibility: Physical activity can alter how cells access their DNA, which may have implications for ageing and cellular health. Changes in DNA accessibility can influence gene expression, potentially promoting genes that support longevity and suppressing those that accelerate ageing


Reference: Murugathasan, Mayoorey, et al. “Moderate exercise induces trained immunity in macrophages.” American Journal of Physiology-Cell Physiology. 24 Jul. 2023,