The promising future of 1,5-AF in age-related diseases

Dec 5, 2023

1,5-anhydro-D-fructose (1,5-AF) shows promising anti-ageing effects on brain diseases associated with ageing. It activates AMPK, enhancing the PGC-1α/BDNF pathway. This activation reduces cerebral infarct volume, neurological deficits, and mortality in acute ischemic stroke models. Additionally, 1,5-AF lowers blood pressure, extends survival, and improves motor cognitive functions in ageing models, suggesting its potential in preventing ageing-related brain diseases.

November 2023 – Aging


Key takeaways


  • 1,5-anhydro-D-fructose activation: 1,5-AF’s ability to activate the AMPK pathway is significant for promoting cellular health. AMPK plays a vital role in maintaining energy homeostasis and managing cellular stress, both of which are crucial factors in the ageing process. By enhancing this pathway, 1,5-AF could contribute to improved overall health and potentially extend lifespan
  • Reduction in brain disease symptoms: The study found that 1,5-AF effectively reduced the severity of symptoms in acute ischemic stroke models. This includes a substantial decrease in the size of cerebral infarcts (areas of dead tissue due to lack of blood flow), along with improvements in neurological function and a reduction in mortality rates. These findings suggest 1,5-AF’s potential in treating or mitigating the effects of stroke and possibly other brain diseases associated with ageing
  • Blood pressure and survival benefits: In ageing models, 1,5-AF demonstrated a capacity to lower blood pressure, a common issue in older adults that can lead to various health complications. Additionally, its use was associated with prolonged survival, indicating its potential as a therapeutic agent for extending life expectancy, particularly in conditions exacerbated by high blood pressure
  • Improvement in cognitive and motor functions: One of the most promising aspects of 1,5-AF is its ability to counteract the decline in motor and cognitive functions often seen in ageing. The compound improved both physical and mental capabilities in ageing models, suggesting it could be beneficial in addressing age-related cognitive decline and maintaining mental acuity and physical agility in older adults


These findings suggest that by activating the AMPK pathway, 1,5-AF shows promise in reducing stroke symptoms, lowering blood pressure, and improving cognitive functions. These results could lead to new therapeutic approaches for enhancing longevity and quality of life in the elderly.


Read the article at: Kikuchi, Kiyoshi, et al. “1,5-Anhydro-D-Fructose Induces Anti-Aging Effects on Aging-Associated Brain Diseases by Increasing 5’-Adenosine Monophosphate-Activated Protein Kinase Activity via the Peroxisome Proliferator-Activated Receptor-γ Co-Activator-1α/Brain-Derived Neurotrophic Factor Pathway.” Aging (Albany NY), vol. 15, 2023, pp. 11740-11763.