SCIENTIFIC RESEARCH

Wearable devices: Future of gene expression

Aug 3, 2023

DART (DC-actuated regulation technology) is an innovative interface that stimulates gene expression in human cells through direct current, showing promising results in reducing hyperglycemia in diabetic mice by boosting insulin production.

 

Key takeaways: An electrogenetic interface to program mammalian gene expression by direct current

 

  • Precise stimulation of gene expression: DART technology allows for the accurate and controlled stimulation of gene expression in human cells, utilising direct current. This precision is crucial for targeting specific genes related to ageing and longevity, potentially unlocking new avenues for age-related disease treatment and healthspan extension
  • Reduction of hyperglycemia in diabetic mice: The technology has shown efficacy in a type 1 diabetic mouse model, where it successfully reduced hyperglycemia by stimulating insulin production. This demonstrates its potential in addressing age-related metabolic disorders and maintaining glucose homeostasis, a key factor in healthy ageing
  • Wearable gene therapy applications: DART’s compatibility with wearable devices opens up possibilities for continuous and on-the-go gene therapy interventions. This could lead to more proactive and responsive healthcare solutions, directly impacting longevity by addressing health issues as they arise
  • Integration with internet of the body and things: By connecting to the Internet of the Body and Internet of Things, DART becomes part of a larger ecosystem of devices and systems. This integration ensures a holistic approach to health management, considering various biological and environmental factors, ultimately contributing to extended healthy living

 

The development of DART marks a significant step forward in the fields of synthetic biology and gene therapy. Its ability to manipulate gene expression in a controlled manner opens up new possibilities for personalised medicine, potentially revolutionising how we address ageing and age-related diseases.

 

Reference: Huang, J., Xue, S., Buchmann, P. et al. An electrogenetic interface to program mammalian gene expression by direct current. Nat Metab 5, 1395–1407 (2023). https://doi.org/10.1038/s42255-023-00850-7