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Exosomes: A breakthrough in joint ageing

Oct 2, 2023

Human umbilical cord mesenchymal stem cells (hUC-MSCs) release exosomes that have anti-inflammatory effects on osteoarthritis-affected chondrocytes, potentially offering a novel treatment for arthritis-related joint degeneration and contributing to longevity by preserving joint health.

September 2023 – Aging

 

Key takeaways

 

  • Anti-inflammatory action: The study suggests that exosomes derived from human umbilical cord mesenchymal stem cells have the ability to mitigate inflammation in the chondrocytes, the cells within joint cartilage. This is significant for longevity as chronic inflammation is a major contributor to the progression of osteoarthritis, which can lead to joint pain and dysfunction with age
  • Cartilage repair and regeneration: These exosomes not only reduce inflammation but also appear to support the repair and maintenance of cartilage tissue. Healthy cartilage is crucial for joint function, and its deterioration is a common issue in ageing populations. By promoting cartilage health, this therapy could help maintain mobility and reduce the age-related decline in joint function
  • Improved joint function: By reducing inflammation and encouraging tissue repair, this treatment has the potential to enhance overall joint function. For individuals concerned with longevity, maintaining joint health is key to preserving independence and quality of life, as it enables continued physical activity and reduces pain
  • Regenerative medicine potential: The use of hUC-MSC-derived exosomes is a cutting-edge example of regenerative medicine, which seeks to repair or replace damaged cells and tissues. This non-invasive approach could offer a novel alternative to more traditional, invasive treatments for osteoarthritis, such as steroid injections or joint replacement surgery, which can carry higher risks and longer recovery times, especially pertinent for the ageing population

 

Read the article at: Wang, S., Jiang, W., et al. “Human Umbilical Cord Mesenchymal Stem Cells-Derived Exosomes Exert Anti-Inflammatory Effects on Osteoarthritis Chondrocytes.Aging (Albany NY), vol. 15, no. 9544-9560, 18 Sep. 2023, https://doi.org/10.18632/aging.205034.