A TERT activator was found to promote telomere synthesis, reduce cellular senescence, and alleviate neuroinflammation in aged mice, improving cognitive function. It achieved this by upregulating TERT transcription through the MEK/ERK/AP-1 pathway, reducing key ageing markers like p16 through DNA methylation, without increasing cancer risk.
Cellular senescence and its impact on metabolic ageing
Cellular senescence, where cells stop dividing but remain metabolically active, leads to the release of harmful molecules that drive ageing and metabolic dysfunction. Addressing the metabolic changes in senescent cells could help reduce ageing effects and related diseases.
POT1 and CST-Polα/primase protect telomeres and support healthy ageing
POT1 recruits and regulates the CST-Polα/primase complex at human telomeres, ensuring proper telomere replication and maintenance. This process is vital for maintaining genome stability, which plays a key role in aging, longevity, and preventing age-related diseases linked to telomere dysfunction.
MYCT1 gene discovery reveals key to blood stem cell renewal and longevity
MYCT1 is essential for how human hematopoietic stem cells (HSCs) sense and respond to their environment, which is crucial for their self-renewal and long-term function. This discovery points to potential therapies that could maintain healthy blood stem cells, support immune function, and enhance longevity by preserving stem cell regenerative abilities.
Life’s essential 8 slows biological ageing and reduces cardiovascular risk
Adhering to “Life’s Essential 8” is associated with reduced cardiovascular disease and mortality, primarily through a younger epigenetic age, underscoring the importance of lifestyle in slowing biological ageing and promoting longevity.
TruAge: How discovering your ‘real age’ can help you age better
TruAge measures biological age using advanced technology to assess gene methylation, telomere length, and stem cell divisions. Learn how the results of this test can guide personalised strategies to slow ageing and optimise health.
Rejuvenating aged stem cells to extend health and lifespan
Key strategies to rejuvenate aged stem cells and extend healthspan and lifespan include physical exercise, diet manipulation, targeting senescence, autophagy, epigenetic reprogramming, and using circulating blood factors. These methods enhance tissue homeostasis and regenerative capacity, potentially improving overall health and longevity.
Efficient DNA-protein crosslink repair enhances longevity
Endogenous aldehyde-induced DNA-protein crosslinks (DPCs) are efficiently resolved by transcription-coupled repair (TCR), protecting against metabolic genotoxins. This process explains the molecular pathogenesis of diseases like AMeDS and Cockayne syndrome. Effective aldehyde clearance and TCR are crucial for maintaining genomic integrity in transcribed regions.
Mitochondrial H2O2 and its indirect role in ageing
Mitochondrial H2O2 release doesn’t directly damage chromosomal DNA but influences ageing through signalling pathways, offering potential targets for anti-ageing interventions.
The impact of genetics and lifestyle on brain ageing and longevity
Genetic and modifiable risk factors affect brain regions vulnerable to aging and diseases like Alzheimer's and schizophrenia. Key factors include diabetes, traffic-related air pollution, and alcohol intake. Modifying these risk factors could help protect these fragile...