Adipose tissue retains an epigenetic ‘memory’ of obesity, even after substantial weight loss. These lasting changes impair fat cell function and heighten susceptibility to weight regain, potentially contributing to the ‘yo-yo’ effect. Targeting this memory could be key to achieving lasting metabolic health and improved longevity.
Optimise your oral microbiome: Habits, products, breathing and more
Your oral microbiome does far more than protect your teeth – it influences immunity, inflammation, and whole-body health. Learn how to optimise it through smarter habits, better product choices, nasal breathing, and targeted strategies to reshape this vital ecosystem.
Restoring senescent cells with sound waves
Low-frequency ultrasound restores the function and growth of senescent cells by reversing ageing markers, enhancing cellular vitality, and extending healthspan and lifespan in mice, offering a non-invasive route to rejuvenation.
AP2A1 reveals new targets for healthy ageing
Reducing AP2A1 levels in aged human cells rejuvenates them by shrinking cell size, softening structural fibres, restoring mobility, and lowering senescence signals.
How trauma during pregnancy shapes future generations
Violence experienced by Syrian refugee women during pregnancy leaves biological marks on future generations, altering DNA methylation and accelerating biological ageing in children. These findings reveal an intergenerational epigenetic signature of trauma, with potential long-term impacts on healthspan and resilience across generations.
Healthspan: Redefining how we approach health and longevity
Healthspan is about living not just longer, but better, full of vitality, energy, and freedom from chronic illness. By uncovering root causes, embracing personalised habits, and shifting from survival mode to thriving, you can build a healthier, more vibrant future
How ageing drives cancer across the lifespan
Aging and cancer are deeply interconnected, influencing one another across the lifespan through immune decline, tissue changes, and cumulative environmental exposures, urging age-tailored approaches to cancer prevention, treatment, and research.
Natural Astragalus supplement shown to lengthen telomeres in midlife
An Astragalus-based supplement taken daily for six months significantly increased telomere length in healthy middle-aged adults, suggesting measurable anti-ageing and longevity benefits without adverse effects.
Gene therapy extends lifespan without cancer risk
Genetic activation of telomerase in mice significantly extended lifespan and improved healing of skin and intestinal injuries, without increasing cancer risk. This targeted intervention boosted cellular repair, antioxidant defences, and telomere length, offering a promising strategy for enhancing longevity and resilience to age-related decline.
The surprising split in ageing research beliefs
Despite major progress in ageing science, researchers hold vastly different views on its causes, definitions, onset, and reversibility. This diversity reveals a critical need for clearer shared understanding, as current disagreements may hinder the development of effective strategies to extend healthspan and tackle biological ageing more precisely.