Regular fasting activates autophagy, reduces oxidative stress and inflammation, delays ageing-related diseases, enhances cellular repair, and promotes longevity by improving metabolic health, making it a promising strategy for healthy ageing and increased healthspan.
The link between blood biomarkers and longevity potential
Lower cholesterol and iron levels, alongside higher glucose, uric acid, and liver enzymes, are associated with a reduced chance of living to 100. These findings suggest a link between specific blood biomarkers and exceptional longevity, offering potential insights into the biological factors behind longer life expectancy.
Rejuvenating aged stem cells to extend health and lifespan
Key strategies to rejuvenate aged stem cells and extend healthspan and lifespan include physical exercise, diet manipulation, targeting senescence, autophagy, epigenetic reprogramming, and using circulating blood factors. These methods enhance tissue homeostasis and regenerative capacity, potentially improving overall health and longevity.
Antioxidants combat age-related diseases by reducing oxidative stress
Antioxidants combat age-related diseases by reducing oxidative stress, potentially enhancing longevity and healthspan. Dietary intake and supplements are highlighted as effective strategies for promoting healthy ageing. October 2022 - Biomedicines Key takeaways...
Therapeutic strategies targeting miRNA and nutraceuticals for longevity
Nutraceuticals and miRNA-mediated pathways influence ageing, with therapeutic strategies targeting these pathways to enhance healthspan and longevity. Diet and molecular interventions hold potential for promoting healthier ageing. March 2024 - Frontiers in Aging...
The impact of genetics and lifestyle on brain ageing and longevity
Genetic and modifiable risk factors affect brain regions vulnerable to aging and diseases like Alzheimer's and schizophrenia. Key factors include diabetes, traffic-related air pollution, and alcohol intake. Modifying these risk factors could help protect these fragile...
Microplastics impact behaviour and inflammation in young and old mice
Short-term exposure to polystyrene microplastics in drinking water caused behavioural changes and increased inflammation in both young and old mice, with age-specific variations in effects. This highlights potential health risks from microplastic pollution across...
Glucose tracking with CGMs: Your longevity ally
CGMs have emerged as a powerful tool for monitoring and improving metabolic health and healthspan. Learn how you can transform this data into new habits to optimise your health.
Long-term health risks of polystyrene microplastics in colorectal cancer cells
Polystyrene microplastics are taken up by colorectal cancer cells, increasing cell migration and potentially promoting metastasis. These particles persist in cells, accumulate in non-proliferating tumour areas, and transfer during cell division, highlighting their...
Vitamin A regulates lineage plasticity to guide stem cell differentiation choices
Vitamin A, via its metabolite all-trans retinoic acid (atRA), controls stem cell differentiation by resolving lineage plasticity. This process is essential for proper tissue repair and maintaining correct cell lineages in the skin, including hair follicles and...