The Body Roundness Index (BRI) has a U-shaped relationship with all-cause mortality, with both very low and high BRI linked to higher death risk. BRI, which reflects visceral fat more accurately than BMI, may serve as a valuable, non-invasive tool for assessing health risks, aiding longevity-focused strategies.
Rapamycin relies on spermidine to boost lifespan and healthspan
Endogenous spermidine is crucial for rapamycin’s benefits, enhancing autophagy and extending lifespan. Blocking spermidine synthesis hinders these effects, highlighting its role in cellular health. Combining rapamycin with spermidine may optimise longevity interventions while mitigating side effects.
Dietary protein tweaks that enhance longevity and healthspan
Restricting dietary isoleucine boosts metabolic health, decreases frailty, and extends lifespan in genetically diverse mice. Male mice benefit most, showing a 33% lifespan increase. This amino acid adjustment offers a promising, calorie-independent way to enhance healthspan and longevity.
Powerful molecules for health and longevity: Our top 20
Discover 20 game-changing molecules that support optimal health and longevity. From enhancing energy and resilience to targeting the hallmarks of ageing, this guide dives into the science behind each molecule and its potential to help you live a longer, healthier life. Spoiler alert: Personalisation is key.
Navigating the festive season: 6 ways to protect your health gains
The festive season doesn’t have to derail your health goals. With mindful strategies like stress management, enjoying treats without guilt, staying active, and prioritising rest, you can maintain balance and vitality. Discover practical tips to navigate the holidays with ease and enjoy the moments that matter most.
Oxidative stress and inflammation: The hidden culprits behind cholesterol’s bad reputation
Cholesterol isn’t the villain it’s made out to be. Learn how oxidative stress and inflammation – not cholesterol itself – are the real culprits behind cardiovascular risks. Discover practical strategies like better hydration, diverse nutrition, and stress management to optimise your health and rethink the cholesterol narrative.
Dietary acid reduction as a pathway to healthy ageing
Reducing dietary acid through increased intake of fruits and vegetables or sodium bicarbonate supplementation slows chronic kidney disease progression, lowers systolic blood pressure, and improves cardiovascular health.
Extending longevity with mitochondrial and omega-3 support
Mitochondrial-targeted supplements like MitoQ, urolithin A, omega-3 fatty acids, and GlyNAC can enhance muscle health and physical function in ageing, potentially extending healthspan and promoting longevity.
Boosting longevity through dietary fibres: The role of β-glucan
β-glucan from plant-based fibres reduced fat, improved glucose tolerance, and boosted energy expenditure in high-fat diet mice, with positive shifts in gut microbiota and increased butyrate levels. Other fibres showed limited impact.
Fasting as a strategy for boosting cellular health and longevity
Regular fasting activates autophagy, reduces oxidative stress and inflammation, delays ageing-related diseases, enhances cellular repair, and promotes longevity by improving metabolic health, making it a promising strategy for healthy ageing and increased healthspan.