Changes in gut bacteria in Parkinson’s disease are associated with lower production of key nutrients and anti-inflammatory compounds, suggesting gut-targeted strategies may help support brain health and slow disease progression.
Fat cells remember obesity even after weight loss
Adipose tissue retains an epigenetic ‘memory’ of obesity, even after substantial weight loss. These lasting changes impair fat cell function and heighten susceptibility to weight regain, potentially contributing to the ‘yo-yo’ effect. Targeting this memory could be key to achieving lasting metabolic health and improved longevity.
Hormesis: Using controlled stress to go harder, faster, stronger, smarter
Discover how small, controlled stressors like fasting, heat, cold, and low-oxygen training can trigger powerful adaptations in the body. Hormesis helps boost resilience, improve performance, sharpen cognition, and support healthy ageing – when done in the right dose.
Optimise your oral microbiome: Habits, products, breathing and more
Your oral microbiome does far more than protect your teeth – it influences immunity, inflammation, and whole-body health. Learn how to optimise it through smarter habits, better product choices, nasal breathing, and targeted strategies to reshape this vital ecosystem.
Torpor-like states reduce biological age in mice
Inducing a torpor-like state in mice significantly slowed blood epigenetic ageing and improved healthspan, revealing that a sustained drop in core body temperature, not calorie restriction or metabolic rate, is key to decelerating molecular ageing and promoting vitality.
Autophagy, mitochondria and mTOR: sulforaphane’s secret to healthy ageing
Sulforaphane triggers fasting-like responses in human cells, enhancing mitochondrial function, autophagy, and nutrient-sensing pathways, while suppressing glucose uptake and mTOR signalling—mimicking the benefits of caloric restriction.
Omega-3 slows biological ageing in older adults
Daily omega-3 slowed biological ageing over three years, with added benefits seen when combined with vitamin D and regular exercise in healthy older adults, based on DNA methylation clocks.
High-dose vitamin D boosts muscle over fat
High-dose vitamin D redirects surplus calories towards muscle growth and away from fat storage by modulating myostatin and leptin signalling. This promotes lean mass, strength, and linear growth without increasing overall weight, offering a new framework for enhancing body composition, energy balance, and metabolic health across the lifespan.
Natural Astragalus supplement shown to lengthen telomeres in midlife
An Astragalus-based supplement taken daily for six months significantly increased telomere length in healthy middle-aged adults, suggesting measurable anti-ageing and longevity benefits without adverse effects.
Living higher, ageing slower: the altitude effect
Higher altitude living in Ethiopia is linked to lower disease burden, reduced DNA damage-related senescence, and longer life expectancy, despite signs of increased facial ageing from UV exposure.