Axolotls exhibit stable DNA methylation beyond early life, suggesting epigenetic resilience linked to negligible senescence. While methylation predicts age during early years, it ceases thereafter, and regeneration events rejuvenate tissues, shedding light on their remarkable longevity and regeneration abilities. This offers molecular insights into ageing stability and tissue renewal.
Rapamycin relies on spermidine to boost lifespan and healthspan
Endogenous spermidine is crucial for rapamycin’s benefits, enhancing autophagy and extending lifespan. Blocking spermidine synthesis hinders these effects, highlighting its role in cellular health. Combining rapamycin with spermidine may optimise longevity interventions while mitigating side effects.
The unique mechanism of DdrC in enhancing DNA stability
DdrC, a DNA repair protein from Deinococcus radiodurans, recognises and stabilises DNA breaks by binding to both single-stranded and double-stranded lesions. It bridges and compacts DNA through a novel mechanism dependent on structural asymmetry, enhancing repair efficiency and supporting the bacterium’s exceptional resistance to DNA damage.
Dietary protein tweaks that enhance longevity and healthspan
Restricting dietary isoleucine boosts metabolic health, decreases frailty, and extends lifespan in genetically diverse mice. Male mice benefit most, showing a 33% lifespan increase. This amino acid adjustment offers a promising, calorie-independent way to enhance healthspan and longevity.
Unique gut mycobiome traits in long-lived individuals
Long-lived individuals exhibit unique gut fungal features, including enriched Candida enterotypes and maintained core taxa like Aspergillus and Penicillium. These fungal patterns, closely linked with beneficial bacterial traits, suggest a role in healthy ageing and longevity through gut microbiome balance and resilience.
Powerful molecules for health and longevity: Our top 20
Discover 20 game-changing molecules that support optimal health and longevity. From enhancing energy and resilience to targeting the hallmarks of ageing, this guide dives into the science behind each molecule and its potential to help you live a longer, healthier life. Spoiler alert: Personalisation is key.
Mitochondria therapy improves stromal cell function and longevity
Artificial mitochondrial transplantation rejuvenates mesenchymal stromal cells, reducing senescence and enhancing anti-inflammatory effects. By transferring healthy mitochondria, aged cells regain energy metabolism, diminish oxidative stress, and improve insulin sensitivity, presenting a promising tool for regenerative therapies targeting ageing and chronic inflammation.
Understanding PFAS and their impact on longevity and ageing
Regulations on per- and polyfluoroalkyl substances (PFAS), known as ‘forever chemicals’, are tightening due to their environmental persistence and potential health risks. Found in consumer products and water sources, stricter guidelines aim to reduce exposure and safeguard public health.
Navigating the festive season: 6 ways to protect your health gains
The festive season doesn’t have to derail your health goals. With mindful strategies like stress management, enjoying treats without guilt, staying active, and prioritising rest, you can maintain balance and vitality. Discover practical tips to navigate the holidays with ease and enjoy the moments that matter most.
Healthspan vs lifespan: What’s the difference?
Discover the difference between living long and living well! Mark’s blog dives into healthspan vs lifespan, explains why biological age matters, and shares how small, impactful lifestyle changes can help you stay healthier for longer.