Intermittent senolytic therapy with dasatinib and quercetin showed no significant decrease in bone resorption in postmenopausal women overall.
Fasting as a strategy for boosting cellular health and longevity
Regular fasting activates autophagy, reduces oxidative stress and inflammation, delays ageing-related diseases, enhances cellular repair, and promotes longevity by improving metabolic health, making it a promising strategy for healthy ageing and increased healthspan.
TERT activation and its potential to reverse ageing markers
A TERT activator was found to promote telomere synthesis, reduce cellular senescence, and alleviate neuroinflammation in aged mice, improving cognitive function. It achieved this by upregulating TERT transcription through the MEK/ERK/AP-1 pathway, reducing key ageing markers like p16 through DNA methylation, without increasing cancer risk.
Cellular senescence and its impact on metabolic ageing
Cellular senescence, where cells stop dividing but remain metabolically active, leads to the release of harmful molecules that drive ageing and metabolic dysfunction. Addressing the metabolic changes in senescent cells could help reduce ageing effects and related diseases.
The top 20 female health leaders of 2024
Longevity, biohacking and science in general can often feel like a domain dominated by male voices. But when you scratch beneath the surface, there are some incredible female voices in the space. Health coach Liv shares her top 20 for 2024.
Cardiorespiratory fitness: A key predictor of lifespan and healthspan
Higher cardiorespiratory fitness (CRF) significantly reduces the risk of chronic diseases and death. Involving 20.9 million participants from 199 studies, this analysis highlights CRF’s crucial role in enhancing healthspan and longevity.
TruAge: How discovering your ‘real age’ can help you age better
TruAge measures biological age using advanced technology to assess gene methylation, telomere length, and stem cell divisions. Learn how the results of this test can guide personalised strategies to slow ageing and optimise health.
Reversing muscle ageing with heavy resistance training
Human skeletal muscle ageing features irregular myofiber shapes, especially in type II fibres, leading to reduced muscle function and mass. Heavy resistance training can reverse these changes, improving muscle health in the elderly.
Biohacking with light: The science and benefits of photobiomodulation
Is photobiomodulation part of your biohacking stack? This non-invasive, scientifically-back method uses red and near-infrared light to boost cellular energy production, aiding in healing, pain relief, muscle recovery, skin health, and neurological conditions.
Therapeutic strategies targeting miRNA and nutraceuticals for longevity
Nutraceuticals and miRNA-mediated pathways influence ageing, with therapeutic strategies targeting these pathways to enhance healthspan and longevity. Diet and molecular interventions hold potential for promoting healthier ageing. March 2024 - Frontiers in Aging...