Changes in gut bacteria in Parkinson’s disease are associated with lower production of key nutrients and anti-inflammatory compounds, suggesting gut-targeted strategies may help support brain health and slow disease progression.
Fat cells remember obesity even after weight loss
Adipose tissue retains an epigenetic ‘memory’ of obesity, even after substantial weight loss. These lasting changes impair fat cell function and heighten susceptibility to weight regain, potentially contributing to the ‘yo-yo’ effect. Targeting this memory could be key to achieving lasting metabolic health and improved longevity.
Hormesis: Using controlled stress to go harder, faster, stronger, smarter
Discover how small, controlled stressors like fasting, heat, cold, and low-oxygen training can trigger powerful adaptations in the body. Hormesis helps boost resilience, improve performance, sharpen cognition, and support healthy ageing – when done in the right dose.
Optimise your oral microbiome: Habits, products, breathing and more
Your oral microbiome does far more than protect your teeth – it influences immunity, inflammation, and whole-body health. Learn how to optimise it through smarter habits, better product choices, nasal breathing, and targeted strategies to reshape this vital ecosystem.
Restoring senescent cells with sound waves
Low-frequency ultrasound restores the function and growth of senescent cells by reversing ageing markers, enhancing cellular vitality, and extending healthspan and lifespan in mice, offering a non-invasive route to rejuvenation.
Torpor-like states reduce biological age in mice
Inducing a torpor-like state in mice significantly slowed blood epigenetic ageing and improved healthspan, revealing that a sustained drop in core body temperature, not calorie restriction or metabolic rate, is key to decelerating molecular ageing and promoting vitality.
Men’s Health Week: Taking control of your health from 30 to 100
Celebrate Men’s Health Week by taking charge of your health at every age. From your 30s to your 90s, discover proactive, data-driven strategies to extend your healthspan, prevent disease, and optimise wellbeing through each decade of life.
AP2A1 reveals new targets for healthy ageing
Reducing AP2A1 levels in aged human cells rejuvenates them by shrinking cell size, softening structural fibres, restoring mobility, and lowering senescence signals.
Restoring the brain’s sugar shield boosts memory
Ageing disrupts a key sugar-protein layer called the glycocalyx lining brain blood vessels, weakening the blood–brain barrier and increasing brain inflammation and cognitive decline; restoring this layer in mice improves brain health and memory.
Autophagy, mitochondria and mTOR: sulforaphane’s secret to healthy ageing
Sulforaphane triggers fasting-like responses in human cells, enhancing mitochondrial function, autophagy, and nutrient-sensing pathways, while suppressing glucose uptake and mTOR signalling—mimicking the benefits of caloric restriction.