Intermittent senolytic therapy with dasatinib and quercetin showed no significant decrease in bone resorption in postmenopausal women overall.
Fasting as a strategy for boosting cellular health and longevity
Regular fasting activates autophagy, reduces oxidative stress and inflammation, delays ageing-related diseases, enhances cellular repair, and promotes longevity by improving metabolic health, making it a promising strategy for healthy ageing and increased healthspan.
TERT activation and its potential to reverse ageing markers
A TERT activator was found to promote telomere synthesis, reduce cellular senescence, and alleviate neuroinflammation in aged mice, improving cognitive function. It achieved this by upregulating TERT transcription through the MEK/ERK/AP-1 pathway, reducing key ageing markers like p16 through DNA methylation, without increasing cancer risk.
Targeting Tregs to extend healthspan and delay the effects of ageing
Regulatory T cells (Tregs) help prevent stem cell exhaustion, a key factor in ageing. As Treg function declines with age, immune imbalance occurs, accelerating the ageing process. This contributes to various age-related diseases. Therapeutically targeting Tregs could slow immuno-ageing, promoting longevity and better health outcomes.
The link between blood biomarkers and longevity potential
Lower cholesterol and iron levels, alongside higher glucose, uric acid, and liver enzymes, are associated with a reduced chance of living to 100. These findings suggest a link between specific blood biomarkers and exceptional longevity, offering potential insights into the biological factors behind longer life expectancy.
Cellular senescence and its impact on metabolic ageing
Cellular senescence, where cells stop dividing but remain metabolically active, leads to the release of harmful molecules that drive ageing and metabolic dysfunction. Addressing the metabolic changes in senescent cells could help reduce ageing effects and related diseases.
Microplastics detected in human seminal fluid: Potential health risks
Microplastics were detected in human seminal fluid, raising concerns about their impact on male reproductive health and potential long-term effects on fertility and ageing. This study used Raman spectroscopy to highlight the prevalence of microplastic contamination in a sample of the general male population.
POT1 and CST-Polα/primase protect telomeres and support healthy ageing
POT1 recruits and regulates the CST-Polα/primase complex at human telomeres, ensuring proper telomere replication and maintenance. This process is vital for maintaining genome stability, which plays a key role in aging, longevity, and preventing age-related diseases linked to telomere dysfunction.
MYCT1 gene discovery reveals key to blood stem cell renewal and longevity
MYCT1 is essential for how human hematopoietic stem cells (HSCs) sense and respond to their environment, which is crucial for their self-renewal and long-term function. This discovery points to potential therapies that could maintain healthy blood stem cells, support immune function, and enhance longevity by preserving stem cell regenerative abilities.
Mitochondrial disposal in ageing heart tissues and its impact on longevity
When lysosomal function is impaired, cells release dysfunctional mitochondria through large extracellular vesicles instead of breaking them down. This process occurs independently of autophagy, helps preserve cellular health, and is observed in aged or diseased heart tissues, offering insights into ageing and cardiac disease.