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Gut inflammation associated with ageing and Alzheimer’s risk

Higher gut inflammation levels are linked with ageing and Alzheimer’s disease, with elevated inflammation markers found in older individuals and those with Alzheimer’s, suggesting intestinal inflammation may contribute to the disease’s progression. November 2023 -...

New hope in Alzheimer’s through metabolic rescue

Aberrant protein S-nitrosylation in Alzheimer's disease inhibits the TCA cycle, causing synaptic loss due to compromised mitochondrial metabolism. Treatment with dimethyl succinate bypasses this block, partially restoring mitochondrial function and reversing synapse...

Brain health’s link to lymphatic drainage

Using fluorescent tracers in mice, researchers discovered that the nasopharyngeal lymphatic plexus is crucial for draining cerebrospinal fluid (CSF) to deep cervical lymph nodes. Unlike its downstream counterparts, this plexus lacks smooth muscle but has unique valves...

Neuroprotection through dietary restriction and OXR1

OXR1, enhanced by dietary restriction, is key in delaying brain ageing. It supports the retromer, crucial for managing protein and lipid movement, thereby offering neuroprotection and aiding longevity. January 2024 - Nature Communications   Key takeaways  ...

Hypothalamic neurons: Key to longer life?

DMHPpp1r17 neurons in the mouse hypothalamus play a crucial role in regulating ageing and lifespan. They influence physical activity and white adipose tissue function, impacting the ageing process. Modifying these neurons' activity can alleviate age-related decline...

The promising future of 1,5-AF in age-related diseases

1,5-anhydro-D-fructose (1,5-AF) shows promising anti-ageing effects on brain diseases associated with ageing. It activates AMPK, enhancing the PGC-1α/BDNF pathway. This activation reduces cerebral infarct volume, neurological deficits, and mortality in acute ischemic...

Optimising Alzheimer’s treatment with plaque clearance

A recent article from ALZFORUM reports that complete removal of amyloid plaques, rather than mere reduction, is essential for clinical benefits in Alzheimer's disease treatments. Early amyloid negativity is linked to slowed tangle buildup, emphasizing the importance...

Fighting brain ageing with senolytic therapy

Senolytic therapy effectively reduces brain ageing and COVID-19 neuropathology by targeting and eliminating senescent cells, offering potential benefits for combating ageing-related cognitive decline. November 2023 - Nature Aging   Key takeaways   Senolytic...

Rejuvenation with young vesicles

Young extracellular vesicles show promise in reversing age-related deterioration in elderly rats and human cellular models, hinting at innovative anti-ageing treatments. July 2023 - Scientific Reports   Key takeaways   Young extracellular vesicles promote...

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