Mitochondrial dysfunction is highlighted as a pivotal element in brain ageing and associated diseases, playing a significant role in energy shortages, elevated oxidative stress, and neuronal harm, driving the advancement of neurodegenerative conditions. March 2024 -...
Sleep enhances brain health and longevity
Neuronal activity boosts cerebrospinal fluid flow to remove brain waste during sleep, potentially affecting longevity and ageing. February 2024 - Nature Key takeaways Neuronal activity enhances fluid flow: The brain's neurons, when active, drive the flow...
Fighting memory loss with KIBRA
KIBRA improves brain connectivity and memory, providing defense against memory decline linked to tauopathy, prevalent in neurodegenerative conditions. February 2024 - Journal of Clinical Investigation Key takeaways Enhanced synaptic plasticity: KIBRA...
Gut inflammation associated with ageing and Alzheimer’s risk
Higher gut inflammation levels are linked with ageing and Alzheimer’s disease, with elevated inflammation markers found in older individuals and those with Alzheimer’s, suggesting intestinal inflammation may contribute to the disease’s progression. November 2023 -...
New hope in Alzheimer’s through metabolic rescue
Aberrant protein S-nitrosylation in Alzheimer's disease inhibits the TCA cycle, causing synaptic loss due to compromised mitochondrial metabolism. Treatment with dimethyl succinate bypasses this block, partially restoring mitochondrial function and reversing synapse...
Brain health’s link to lymphatic drainage
Using fluorescent tracers in mice, researchers discovered that the nasopharyngeal lymphatic plexus is crucial for draining cerebrospinal fluid (CSF) to deep cervical lymph nodes. Unlike its downstream counterparts, this plexus lacks smooth muscle but has unique valves...
Neuroprotection through dietary restriction and OXR1
OXR1, enhanced by dietary restriction, is key in delaying brain ageing. It supports the retromer, crucial for managing protein and lipid movement, thereby offering neuroprotection and aiding longevity. January 2024 - Nature Communications Key takeaways ...
Hypothalamic neurons: Key to longer life?
DMHPpp1r17 neurons in the mouse hypothalamus play a crucial role in regulating ageing and lifespan. They influence physical activity and white adipose tissue function, impacting the ageing process. Modifying these neurons' activity can alleviate age-related decline...
Protective effects of apigenin on brain health and cognitive function
Apigenin improves memory and learning in older mice by modulating immune and inflammation-related genes. It also reduces inflammation and cellular ageing in astrocytes, potentially protecting against age-related cognitive decline. November 2023 - Mechanisms of Ageing...
The promising future of 1,5-AF in age-related diseases
1,5-anhydro-D-fructose (1,5-AF) shows promising anti-ageing effects on brain diseases associated with ageing. It activates AMPK, enhancing the PGC-1α/BDNF pathway. This activation reduces cerebral infarct volume, neurological deficits, and mortality in acute ischemic...
Have something to add, or want to ask something? Join the conversation in the comments below and we’d be delighted to chat.