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Fighting memory loss with KIBRA

KIBRA improves brain connectivity and memory, providing defense against memory decline linked to tauopathy, prevalent in neurodegenerative conditions. February 2024 - Journal of Clinical Investigation   Key takeaways   Enhanced synaptic plasticity: KIBRA...

Red ginseng supports liver health and healthy ageing

Red Ginseng (RG) has been shown to improve insulin homeostasis and modulate cellular ageing processes in aged mice. It effectively reduces inflammation and cellular senescence in the liver, suggesting its potential as a beneficial supplement for ageing-related...

Senescent cells: Targeting with CAR T therapy

Senolytic CAR T cells targeting senescent cells rejuvenate metabolic function in old mice, with a single dose offering long-lasting preventive effects against age-related metabolic dysfunction, highlighting a promising approach for improving healthspan. January 2024 -...

Gut inflammation associated with ageing and Alzheimer’s risk

Higher gut inflammation levels are linked with ageing and Alzheimer’s disease, with elevated inflammation markers found in older individuals and those with Alzheimer’s, suggesting intestinal inflammation may contribute to the disease’s progression. November 2023 -...

Alzheimer’s risk in hormone therapy recipients

A small group of patients treated with contaminated cadaveric pituitary-derived growth hormone, containing amyloid-beta seeds, developed Alzheimer’s disease years later, highlighting a potential treatment-induced route of Alzheimer’s transmission and emphasizing the...

New hope in Alzheimer’s through metabolic rescue

Aberrant protein S-nitrosylation in Alzheimer's disease inhibits the TCA cycle, causing synaptic loss due to compromised mitochondrial metabolism. Treatment with dimethyl succinate bypasses this block, partially restoring mitochondrial function and reversing synapse...

Brain health’s link to lymphatic drainage

Using fluorescent tracers in mice, researchers discovered that the nasopharyngeal lymphatic plexus is crucial for draining cerebrospinal fluid (CSF) to deep cervical lymph nodes. Unlike its downstream counterparts, this plexus lacks smooth muscle but has unique valves...

Hypothalamic neurons: Key to longer life?

DMHPpp1r17 neurons in the mouse hypothalamus play a crucial role in regulating ageing and lifespan. They influence physical activity and white adipose tissue function, impacting the ageing process. Modifying these neurons' activity can alleviate age-related decline...

Reversing age with stress recovery

Biological age is dynamic and can rapidly change in response to stress, as observed in young mice and humans. Stress increases biological age, but this effect can be reversed upon recovery. This phenomenon is evident at epigenetic, transcriptomic, and metabolomic...

Breakthrough in cancer treatment: Molecular jackhammers

Molecular jackhammers activate vibronic modes in single molecules, efficiently destroying cancer cells by mechanically disassembling their membranes, offering a potential alternative to traditional cancer therapies with fewer side effects. December 2023 - Nature...

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