Metformin increases autophagy in the liver and intestines and reduces ageing-related inflammatory factors in elderly rats, indicating its potential to combat ageing-related diseases and promote longevity. December 2023 - Experimental Gerontology Key takeaways...
Strengthening immunity with short-term fasting
Dietary restriction enhances T cell immunity, balancing homeostasis and reducing inflammation. While long-term fasting weakens T cell response due to increased autophagy and apoptosis, short-term restriction boosts T cell function. July 2023 - Cellular and Molecular...
Autophagy’s role in preventing vision loss with age
A 2023 study has highlighted the pivotal role of autophagy in age-related macular degeneration (AMD). Autophagy, especially in the retinal pigment epithelium (RPE), is crucial for clearing harmful reactive oxygen species and damaged mitochondria. The research...
New AI-predicted mTOR inhibitor shows promise in cancer treatment and ageing
The mechanistic target of rapamycin (mTOR) kinase is one of the top drug targets for promoting health and lifespan extension. Besides rapamycin, only a few other mTOR inhibitors have been developed and shown their ability to slow ageing. In this study, machine...
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