Red and near-infrared LED irradiation shows promise in treating otitis media (OM), a middle ear inflammatory condition. By applying this treatment in a rat model and cell lines, researchers observed a significant reduction in ear mucosal thickness, inflammatory cells,...
Protective effects of apigenin on brain health and cognitive function
Apigenin improves memory and learning in older mice by modulating immune and inflammation-related genes. It also reduces inflammation and cellular ageing in astrocytes, potentially protecting against age-related cognitive decline. November 2023 - Mechanisms of Ageing...
Tackling age-related dental issues with RvE1
Resolvin E1 (RvE1) shows promise in dental pulp regeneration, enhancing Axin2-expressing cell proliferation and differentiation. It modulates inflammation, reduces infection severity, and prevents apical periodontitis, offering a new treatment approach for endodontic...
Metformin’s role in enhancing autophagy and reducing inflammation
Metformin increases autophagy in the liver and intestines and reduces ageing-related inflammatory factors in elderly rats, indicating its potential to combat ageing-related diseases and promote longevity. December 2023 - Experimental Gerontology Key takeaways...
mtDNA’s impact on senescence and ageing
During cellular senescence, cells eject mitochondrial DNA, sparking an inflammatory response that contributes to ageing. This process could be key in developing anti-ageing interventions. October 2023 - Nature Key takeaways Mitochondrial DNA release: As...
Exosomes: A breakthrough in joint ageing
Human umbilical cord mesenchymal stem cells (hUC-MSCs) release exosomes that have anti-inflammatory effects on osteoarthritis-affected chondrocytes, potentially offering a novel treatment for arthritis-related joint degeneration and contributing to longevity by...
Inflammation and ageing: Genetic connections
Anti-ageing interventions appear to converge on a cellular level, consistently downregulating genes associated with inflammation and upregulating those involved in fatty acid metabolism. This dual action at the genetic expression level may be a key mechanism by which...
Halting ageing: cGAS-STING pathway insights
The cGAS–STING signaling pathway contributes significantly to chronic inflammation and functional deterioration associated with ageing, indicating its potential as a therapeutic target to combat neurodegeneration in later life. August 2023 - Nature Key...
Redefining age: Insights from the PCAge clock
The PCAge clinical ageing clock identifies healthy and unhealthy ageing patterns. Using ACE-Is or ARBs reduces mortality risk and slows biological age acceleration, offering a proactive approach to ageing and age-related diseases. Key takeaways: The principal...
The link between moderate workouts and ageing well
Moderate exercise in mice results in metabolic and epigenetic alterations in macrophages, diminishing their inflammatory reactions. This activity enhances cellular oxygen use, decreases damaging compounds, and modifies DNA accessibility, providing insights into...
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