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Fighting memory loss with KIBRA

KIBRA improves brain connectivity and memory, providing defense against memory decline linked to tauopathy, prevalent in neurodegenerative conditions. February 2024 - Journal of Clinical Investigation   Key takeaways   Enhanced synaptic plasticity: KIBRA...

Red ginseng supports liver health and healthy ageing

Red Ginseng (RG) has been shown to improve insulin homeostasis and modulate cellular ageing processes in aged mice. It effectively reduces inflammation and cellular senescence in the liver, suggesting its potential as a beneficial supplement for ageing-related...

Senescent cells: Targeting with CAR T therapy

Senolytic CAR T cells targeting senescent cells rejuvenate metabolic function in old mice, with a single dose offering long-lasting preventive effects against age-related metabolic dysfunction, highlighting a promising approach for improving healthspan. January 2024 -...

Gut inflammation associated with ageing and Alzheimer’s risk

Higher gut inflammation levels are linked with ageing and Alzheimer’s disease, with elevated inflammation markers found in older individuals and those with Alzheimer’s, suggesting intestinal inflammation may contribute to the disease’s progression. November 2023 -...

Alzheimer’s risk in hormone therapy recipients

A small group of patients treated with contaminated cadaveric pituitary-derived growth hormone, containing amyloid-beta seeds, developed Alzheimer’s disease years later, highlighting a potential treatment-induced route of Alzheimer’s transmission and emphasizing the...

New hope in Alzheimer’s through metabolic rescue

Aberrant protein S-nitrosylation in Alzheimer's disease inhibits the TCA cycle, causing synaptic loss due to compromised mitochondrial metabolism. Treatment with dimethyl succinate bypasses this block, partially restoring mitochondrial function and reversing synapse...

Brain health’s link to lymphatic drainage

Using fluorescent tracers in mice, researchers discovered that the nasopharyngeal lymphatic plexus is crucial for draining cerebrospinal fluid (CSF) to deep cervical lymph nodes. Unlike its downstream counterparts, this plexus lacks smooth muscle but has unique valves...

Reversing ageing in blood stem cells

Epigenetic changes in ageing hematopoietic stem cells are linked to hematologic disorders, highlighting the importance of DNA methylation and histone modifications. December 2023 - Epigenomes   Key takeaways   Ageing in hematopoietic stem cells: The natural...

LED irradiation: A breakthrough in otitis media treatment

Red and near-infrared LED irradiation shows promise in treating otitis media (OM), a middle ear inflammatory condition. By applying this treatment in a rat model and cell lines, researchers observed a significant reduction in ear mucosal thickness, inflammatory cells,...

Neuroprotection through dietary restriction and OXR1

OXR1, enhanced by dietary restriction, is key in delaying brain ageing. It supports the retromer, crucial for managing protein and lipid movement, thereby offering neuroprotection and aiding longevity. January 2024 - Nature Communications   Key takeaways  ...

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