The ApoE4 gene variant may accelerate tau pathology at lower amyloid levels in Alzheimer's disease, influencing disease progression and treatment strategies. November 2023 - JAMA Neurology Key takeaways ApoE4 and tau pathology: Individuals carrying the...
Inflammation and ageing: Genetic connections
Anti-ageing interventions appear to converge on a cellular level, consistently downregulating genes associated with inflammation and upregulating those involved in fatty acid metabolism. This dual action at the genetic expression level may be a key mechanism by which...
Mole-rat gene boosts mouse lifespan
Transgenic mice expressing the naked mole-rat hyaluronic acid synthase 2 gene (nmrHAS2) demonstrated increased hyaluronan, reduced cancer incidence, and enhanced lifespan and healthspan. This effect is linked to the anti-inflammatory and antioxidant properties of high...
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