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Fighting memory loss with KIBRA

KIBRA improves brain connectivity and memory, providing defense against memory decline linked to tauopathy, prevalent in neurodegenerative conditions. February 2024 - Journal of Clinical Investigation   Key takeaways   Enhanced synaptic plasticity: KIBRA...

Hypothalamic neurons: Key to longer life?

DMHPpp1r17 neurons in the mouse hypothalamus play a crucial role in regulating ageing and lifespan. They influence physical activity and white adipose tissue function, impacting the ageing process. Modifying these neurons' activity can alleviate age-related decline...

The promising future of 1,5-AF in age-related diseases

1,5-anhydro-D-fructose (1,5-AF) shows promising anti-ageing effects on brain diseases associated with ageing. It activates AMPK, enhancing the PGC-1α/BDNF pathway. This activation reduces cerebral infarct volume, neurological deficits, and mortality in acute ischemic...

Mitochondrial dysfunction predictive factor for cognitive decline

Mitochondrial dysfunction in skeletal muscles is potentially linked to cognitive impairment and biomarkers of Alzheimer's disease, suggesting a connection between muscle health and brain health in ageing and neurodegeneration. October 2023 - Alzheimer's & Dementia...

Fighting brain ageing with senolytic therapy

Senolytic therapy effectively reduces brain ageing and COVID-19 neuropathology by targeting and eliminating senescent cells, offering potential benefits for combating ageing-related cognitive decline. November 2023 - Nature Aging   Key takeaways   Senolytic...

Reversing age with platelet factors

Young blood plasma and platelet factors show promise in altering gene expression to boost immune function and nervous system health, potentially reversing cognitive decline associated with ageing. August 2023 - Nature   Key takeaways   Gene expression...

Breathing’s role in memory and ageing

Breathing not only sustains life but also significantly impacts memory. Controlled breathing during memory formation can sharpen cognitive functions, suggesting a potential strategy for enhancing memory performance and contributing to healthier ageing. July 2023 -...

Rejuvenation with young vesicles

Young extracellular vesicles show promise in reversing age-related deterioration in elderly rats and human cellular models, hinting at innovative anti-ageing treatments. July 2023 - Scientific Reports   Key takeaways   Young extracellular vesicles promote...

Enhancing brain health through HMB

HMB, a muscle-building supplement, binds to PPARα, enhancing hippocampal functions and reducing Alzheimer’s disease plaques in mice. This interaction highlights HMB's potential as a neuroprotective agent, opening avenues for its use in combating cognitive decline and...

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