Ergothioneine, a dietary supplement, effectively increases lifespan and reduces age-related declines in physical and cognitive functions in male mice. Regular intake shows promise in promoting longevity and mitigating the effects of ageing. March 2024 - GeroScience...
Mitochondrial dysfunction influences brain ageing and disease
Mitochondrial dysfunction is highlighted as a pivotal element in brain ageing and associated diseases, playing a significant role in energy shortages, elevated oxidative stress, and neuronal harm, driving the advancement of neurodegenerative conditions. March 2024 -...
Fighting memory loss with KIBRA
KIBRA improves brain connectivity and memory, providing defense against memory decline linked to tauopathy, prevalent in neurodegenerative conditions. February 2024 - Journal of Clinical Investigation Key takeaways Enhanced synaptic plasticity: KIBRA...
Hypothalamic neurons: Key to longer life?
DMHPpp1r17 neurons in the mouse hypothalamus play a crucial role in regulating ageing and lifespan. They influence physical activity and white adipose tissue function, impacting the ageing process. Modifying these neurons' activity can alleviate age-related decline...
Protective effects of apigenin on brain health and cognitive function
Apigenin improves memory and learning in older mice by modulating immune and inflammation-related genes. It also reduces inflammation and cellular ageing in astrocytes, potentially protecting against age-related cognitive decline. November 2023 - Mechanisms of Ageing...
The promising future of 1,5-AF in age-related diseases
1,5-anhydro-D-fructose (1,5-AF) shows promising anti-ageing effects on brain diseases associated with ageing. It activates AMPK, enhancing the PGC-1α/BDNF pathway. This activation reduces cerebral infarct volume, neurological deficits, and mortality in acute ischemic...
Mitochondrial dysfunction predictive factor for cognitive decline
Mitochondrial dysfunction in skeletal muscles is potentially linked to cognitive impairment and biomarkers of Alzheimer's disease, suggesting a connection between muscle health and brain health in ageing and neurodegeneration. October 2023 - Alzheimer's & Dementia...
Fighting brain ageing with senolytic therapy
Senolytic therapy effectively reduces brain ageing and COVID-19 neuropathology by targeting and eliminating senescent cells, offering potential benefits for combating ageing-related cognitive decline. November 2023 - Nature Aging Key takeaways Senolytic...
Reversing age with platelet factors
Young blood plasma and platelet factors show promise in altering gene expression to boost immune function and nervous system health, potentially reversing cognitive decline associated with ageing. August 2023 - Nature Key takeaways Gene expression...
Breathing’s role in memory and ageing
Breathing not only sustains life but also significantly impacts memory. Controlled breathing during memory formation can sharpen cognitive functions, suggesting a potential strategy for enhancing memory performance and contributing to healthier ageing. July 2023 -...
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