Astaxanthin and meclizine extended male mouse lifespans by 12% and 8%, respectively, when started at 12 months of age. However, they had no significant effect on female mice. Other tested compounds, including fisetin and dimethyl fumarate, showed no notable impact on...
Balancing mTOR for healthy ageing
The mTOR signaling pathway is crucial for cell growth and metabolism, affecting aging and disease. Properly regulating mTOR could treat age-related conditions and potentially extend lifespan, but careful modulation is essential to prevent negative side effects....
Neuronal mTORC1’s role in longevity
Inhibiting mTORC1 in C. elegans' neurons extends lifespan without hindering growth and reproduction, offering a potential pathway to promote longevity while maintaining life quality. September 2023 - PLOS Genetics Key takeaways Neuronal mTORC1 inhibition...
Rapamycin: A key to longevity?
Rapamycin, an mTOR inhibitor, holds untapped potential for extending life and improving health. Despite its promise in anti-ageing, societal and scientific challenges have slowed its adoption in longevity treatments. October 2019 - Aging Key takeaways ...
Exploring the checkered past of rapamycin: a breakthrough in anti-aging research
This article discusses the interesting story of a drug called rapamycin, which has shown potential as an anti-ageing treatment. Rapamycin was accidentally discovered on Easter Island in the 1970s while scientists were studying soil samples. Originally, it was used as...
New AI-predicted mTOR inhibitor shows promise in cancer treatment and ageing
The mechanistic target of rapamycin (mTOR) kinase is one of the top drug targets for promoting health and lifespan extension. Besides rapamycin, only a few other mTOR inhibitors have been developed and shown their ability to slow ageing. In this study, machine...
Have something to add, or want to ask something? Join the conversation in the comments below and we’d be delighted to chat.