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Red ginseng supports liver health and healthy ageing

Red Ginseng (RG) has been shown to improve insulin homeostasis and modulate cellular ageing processes in aged mice. It effectively reduces inflammation and cellular senescence in the liver, suggesting its potential as a beneficial supplement for ageing-related...

Glial mitochondrial signals impact neuronal proteostasis and ageing

Glial cells, when detecting mitochondrial stress, send signals to neurons that help maintain protein balance and reduce protein aggregation. This communication between glia and neurons is key in regulating protein homeostasis, significantly influencing the aging...

Breakthrough in cancer treatment: Molecular jackhammers

Molecular jackhammers activate vibronic modes in single molecules, efficiently destroying cancer cells by mechanically disassembling their membranes, offering a potential alternative to traditional cancer therapies with fewer side effects. December 2023 - Nature...

Fisetin supplementation for cellular senescence reduction

Fisetin, a natural compound, has been found to improve arterial function in old mice by reducing cellular senescence. This was achieved through intermittent dosing, which led to enhanced endothelial function and decreased arterial stiffness. The improvements were...

Astaxanthin and meclizine extend lifespan in male mice

Astaxanthin and meclizine extended male mouse lifespans by 12% and 8%, respectively, when started at 12 months of age. However, they had no significant effect on female mice. Other tested compounds, including fisetin and dimethyl fumarate, showed no notable impact on...

mtDNA’s impact on senescence and ageing

During cellular senescence, cells eject mitochondrial DNA, sparking an inflammatory response that contributes to ageing. This process could be key in developing anti-ageing interventions. October 2023 - Nature   Key takeaways   Mitochondrial DNA release: As...

Balancing mTOR for healthy ageing

The mTOR signaling pathway is crucial for cell growth and metabolism, affecting aging and disease. Properly regulating mTOR could treat age-related conditions and potentially extend lifespan, but careful modulation is essential to prevent negative side effects....

The hidden ageing factor: microplastics in food

Microwave heating of plastic containers releases the highest amount of microplastics and nanoplastics into food. Some containers release billions of particles in just 3 minutes.   Key takeaways: Assessing the release of microplastics and nanoplastics from plastic...

Exploring α-KG’s role in promoting cellular health

Metabolic reprogramming, especially the dysregulation of glutamine metabolism, is pivotal in tumorigenesis and resistance to therapy. Elevated glutamine metabolic pathways were observed in patients with primary DLBCL. However, the glutamine derivative,...

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