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Reversing ageing in blood stem cells

Epigenetic changes in ageing hematopoietic stem cells are linked to hematologic disorders, highlighting the importance of DNA methylation and histone modifications. December 2023 - Epigenomes   Key takeaways   Ageing in hematopoietic stem cells: The natural...

Reversing age with stress recovery

Biological age is dynamic and can rapidly change in response to stress, as observed in young mice and humans. Stress increases biological age, but this effect can be reversed upon recovery. This phenomenon is evident at epigenetic, transcriptomic, and metabolomic...

The relationship between green space exposure and longevity

Greater exposure to neighbourhood green space is initially linked to longer telomeres, indicating potential health benefits. However, this association diminishes when considering additional factors like air pollution and neighbourhood deprivation, underscoring the...

HiPS cells and the future of epigenetic reprogramming

Transient naive reprogramming is a new method for creating human induced pluripotent stem cells (hiPS cells) from somatic cells, resulting in cells with epigenetic and functional characteristics remarkably similar to human embryonic stem cells. This technique...

Epigenetic drift’s link to mammal lifespan

Epigenetic drift, characterised by the loss of epigenetic patterning, varies with the lifespan of different mammals. Shorter-lived species like rats and mice show a faster accumulation of epigenetic disorder compared to longer-lived species such as dogs and baboons....

Reversing age with young blood

Exposure to young blood circulation in mice leads to a substantial reduction in epigenetic ageing, with lasting effects even after the youthful circulation is removed. This discovery opens avenues for potential interventions in age-related diseases and longevity...

The shared epigenetic footprint of age and cancer

Ageing and cancer share an epigenetic replication signature, suggesting age-related replication may drive cells towards a tumorigenic state.   Key takeaways: More than bad luck: Cancer and aging are linked to replication-driven changes to the epigenome  ...

Epigenetics and ageing: a chemical rejuvenation approach

Researchers have identified that a loss of epigenetic information is a hallmark of eukaryotic ageing, which can be reversed. Previously, the induction of Yamanaka factors in mammals was shown to restore youthful DNA methylation patterns and tissue function. In this...

Green spaces: a secret to slower ageing?

A recent study explored the relationship between urban greenness and biological ageing, revealing that exposure to urban greenness is associated with slower epigenetic ageing. However, disparities exist, as Black participants and those in socioeconomically...

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