Senolytic drugs dasatinib, quercetin, and fisetin may influence longevity and age-related decline by affecting DNA methylation clocks. February 2024 - Aging Key takeaways Dasatinib, quercetin, and fisetin's impact on ageing: These compounds may influence...
Red ginseng supports liver health and healthy ageing
Red Ginseng (RG) has been shown to improve insulin homeostasis and modulate cellular ageing processes in aged mice. It effectively reduces inflammation and cellular senescence in the liver, suggesting its potential as a beneficial supplement for ageing-related...
Senescent cells: Targeting with CAR T therapy
Senolytic CAR T cells targeting senescent cells rejuvenate metabolic function in old mice, with a single dose offering long-lasting preventive effects against age-related metabolic dysfunction, highlighting a promising approach for improving healthspan. January 2024 -...
Fisetin supplementation for cellular senescence reduction
Fisetin, a natural compound, has been found to improve arterial function in old mice by reducing cellular senescence. This was achieved through intermittent dosing, which led to enhanced endothelial function and decreased arterial stiffness. The improvements were...
mtDNA’s impact on senescence and ageing
During cellular senescence, cells eject mitochondrial DNA, sparking an inflammatory response that contributes to ageing. This process could be key in developing anti-ageing interventions. October 2023 - Nature Key takeaways Mitochondrial DNA release: As...
Balancing ageing: Senescent cells’ dual roles
Senescent cells are implicated in both the ageing process and chronic diseases, but they also help maintain tissue balance, offering avenues for therapies to foster healthy ageing. September 2023 - Aging Cell Key takeaways Senescent cell accumulation: As...
Rejuvenation with young vesicles
Young extracellular vesicles show promise in reversing age-related deterioration in elderly rats and human cellular models, hinting at innovative anti-ageing treatments. July 2023 - Scientific Reports Key takeaways Young extracellular vesicles promote...
Senescence markers reduced in skin
A senotherapeutic peptide significantly reduces biological age and cellular senescence in human skin, indicating a potential breakthrough in anti-ageing treatments. May 2023 - npj Aging Key takeaways Rejuvenation of aged skin: The peptide treatment...
Senescence signals: surprising allies in whole-body regeneration
Researchers have discovered a fascinating link between cellular senescence and whole-body regeneration in the cnidarian Hydractinia symbiolongicarpus. The study reveals that senescent cells, typically associated with ageing and inflammation, can instruct neighboring...
How stress affects ageing: Insights from a new study
New research reveals that physiological stress load may accelerate ageing by affecting immune cells. The study found that stress load correlates with age and is linked to changes in T lymphocyte subsets, which are crucial for immune response. This suggests that...
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