Melbourne Functional Medicine logo

Red ginseng supports liver health and healthy ageing

Red Ginseng (RG) has been shown to improve insulin homeostasis and modulate cellular ageing processes in aged mice. It effectively reduces inflammation and cellular senescence in the liver, suggesting its potential as a beneficial supplement for ageing-related...

Senescent cells: Targeting with CAR T therapy

Senolytic CAR T cells targeting senescent cells rejuvenate metabolic function in old mice, with a single dose offering long-lasting preventive effects against age-related metabolic dysfunction, highlighting a promising approach for improving healthspan. January 2024 -...

Fisetin supplementation for cellular senescence reduction

Fisetin, a natural compound, has been found to improve arterial function in old mice by reducing cellular senescence. This was achieved through intermittent dosing, which led to enhanced endothelial function and decreased arterial stiffness. The improvements were...

mtDNA’s impact on senescence and ageing

During cellular senescence, cells eject mitochondrial DNA, sparking an inflammatory response that contributes to ageing. This process could be key in developing anti-ageing interventions. October 2023 - Nature   Key takeaways   Mitochondrial DNA release: As...

Balancing ageing: Senescent cells’ dual roles

Senescent cells are implicated in both the ageing process and chronic diseases, but they also help maintain tissue balance, offering avenues for therapies to foster healthy ageing. September 2023 - Aging Cell   Key takeaways   Senescent cell accumulation: As...

Rejuvenation with young vesicles

Young extracellular vesicles show promise in reversing age-related deterioration in elderly rats and human cellular models, hinting at innovative anti-ageing treatments. July 2023 - Scientific Reports   Key takeaways   Young extracellular vesicles promote...

Senescence markers reduced in skin

A senotherapeutic peptide significantly reduces biological age and cellular senescence in human skin, indicating a potential breakthrough in anti-ageing treatments. May 2023 - npj Aging   Key takeaways   Rejuvenation of aged skin: The peptide treatment...

Senescence signals: surprising allies in whole-body regeneration

Researchers have discovered a fascinating link between cellular senescence and whole-body regeneration in the cnidarian Hydractinia symbiolongicarpus. The study reveals that senescent cells, typically associated with ageing and inflammation, can instruct neighboring...

How stress affects ageing: Insights from a new study

New research reveals that physiological stress load may accelerate ageing by affecting immune cells. The study found that stress load correlates with age and is linked to changes in T lymphocyte subsets, which are crucial for immune response. This suggests that...

Exploring neuroregeneration through senolytic cocktails

A recent study has found that the African turquoise killifish, known for its high regenerative abilities, loses this capacity as it ages, adopting a limited form of mammalian regeneration. Researchers used a proteomic strategy (analysing the proteins) to understand...

Have something to add, or want to ask something? Join the conversation in the comments below and we’d be delighted to chat.