Senolytic drugs dasatinib, quercetin, and fisetin may influence longevity and age-related decline by affecting DNA methylation clocks. February 2024 - Aging Key takeaways Dasatinib, quercetin, and fisetin's impact on ageing: These compounds may influence...
Reversing ageing in blood stem cells
Epigenetic changes in ageing hematopoietic stem cells are linked to hematologic disorders, highlighting the importance of DNA methylation and histone modifications. December 2023 - Epigenomes Key takeaways Ageing in hematopoietic stem cells: The natural...
Epigenetic drift’s link to mammal lifespan
Epigenetic drift, characterised by the loss of epigenetic patterning, varies with the lifespan of different mammals. Shorter-lived species like rats and mice show a faster accumulation of epigenetic disorder compared to longer-lived species such as dogs and baboons....
The link between gut health and ageing acceleration
Gut bacteria may causally influence biological ageing by altering DNA methylation, with implications for microbiota-focused longevity therapies. November 2023 - Scientific Reports Key takeaways Gut microbiota's causal role: The diversity and presence of...
New DNA clock measures mammalian ageing
A universal DNA methylation-based clock accurately estimates age across different mammalian tissues, aiding ageing research and the pursuit of longevity interventions. August 2023 - Nature Aging Key takeaways Refined accuracy of universal DNA methylation clock:...
Senescence markers reduced in skin
A senotherapeutic peptide significantly reduces biological age and cellular senescence in human skin, indicating a potential breakthrough in anti-ageing treatments. May 2023 - npj Aging Key takeaways Rejuvenation of aged skin: The peptide treatment...
Epigenetics and ageing: a chemical rejuvenation approach
Researchers have identified that a loss of epigenetic information is a hallmark of eukaryotic ageing, which can be reversed. Previously, the induction of Yamanaka factors in mammals was shown to restore youthful DNA methylation patterns and tissue function. In this...
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