Diminished mitochondrial calcium uptake in macrophages accelerates age-related inflammation, offering new insights into ageing mechanisms and potential therapeutic targets. Key takeaways: Reduced mitochondrial calcium uptake in macrophages is a major driver of...
Inflammaging: the silent driver of age-related diseases
A recent study explored the updated hallmarks of ageing, emphasising the role of chronic inflammation, termed "inflammaging." This low-grade inflammation, prevalent during ageing without apparent infection, is linked to higher morbidity and mortality in the elderly....
Immunosenescence: Investigating molecular mechanisms and their impact on diseases
Immunosenescence, the age-related decline in immune function, is associated with increased susceptibility to infections, reduced effectiveness of vaccinations, earlier onset of age-related diseases, and the development of neoplasms. Ageing organisms exhibit a chronic...
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