Senolytic drugs dasatinib, quercetin, and fisetin may influence longevity and age-related decline by affecting DNA methylation clocks. February 2024 - Aging Key takeaways Dasatinib, quercetin, and fisetin's impact on ageing: These compounds may influence...
Senescent cells: Targeting with CAR T therapy
Senolytic CAR T cells targeting senescent cells rejuvenate metabolic function in old mice, with a single dose offering long-lasting preventive effects against age-related metabolic dysfunction, highlighting a promising approach for improving healthspan. January 2024 -...
Fighting brain ageing with senolytic therapy
Senolytic therapy effectively reduces brain ageing and COVID-19 neuropathology by targeting and eliminating senescent cells, offering potential benefits for combating ageing-related cognitive decline. November 2023 - Nature Aging Key takeaways Senolytic...
Balancing ageing: Senescent cells’ dual roles
Senescent cells are implicated in both the ageing process and chronic diseases, but they also help maintain tissue balance, offering avenues for therapies to foster healthy ageing. September 2023 - Aging Cell Key takeaways Senescent cell accumulation: As...
Exploring neuroregeneration through senolytic cocktails
A recent study has found that the African turquoise killifish, known for its high regenerative abilities, loses this capacity as it ages, adopting a limited form of mammalian regeneration. Researchers used a proteomic strategy (analysing the proteins) to understand...
Zoledronic acid: A breakthrough in longevity research
Zoledronic acid, a medication known for reducing fracture risk, has shown potential benefits beyond skeletal health. Some studies indicate that it can decrease mortality in humans and extend both lifespan and health span in animals. These additional effects may be...
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