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Senescent cells: Targeting with CAR T therapy

Senolytic CAR T cells targeting senescent cells rejuvenate metabolic function in old mice, with a single dose offering long-lasting preventive effects against age-related metabolic dysfunction, highlighting a promising approach for improving healthspan. January 2024 -...

Fighting brain ageing with senolytic therapy

Senolytic therapy effectively reduces brain ageing and COVID-19 neuropathology by targeting and eliminating senescent cells, offering potential benefits for combating ageing-related cognitive decline. November 2023 - Nature Aging   Key takeaways   Senolytic...

Balancing ageing: Senescent cells’ dual roles

Senescent cells are implicated in both the ageing process and chronic diseases, but they also help maintain tissue balance, offering avenues for therapies to foster healthy ageing. September 2023 - Aging Cell   Key takeaways   Senescent cell accumulation: As...

Exploring neuroregeneration through senolytic cocktails

A recent study has found that the African turquoise killifish, known for its high regenerative abilities, loses this capacity as it ages, adopting a limited form of mammalian regeneration. Researchers used a proteomic strategy (analysing the proteins) to understand...

Zoledronic acid: A breakthrough in longevity research

Zoledronic acid, a medication known for reducing fracture risk, has shown potential benefits beyond skeletal health. Some studies indicate that it can decrease mortality in humans and extend both lifespan and health span in animals. These additional effects may be...

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