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Gut inflammation associated with ageing and Alzheimer’s risk

Higher gut inflammation levels are linked with ageing and Alzheimer’s disease, with elevated inflammation markers found in older individuals and those with Alzheimer’s, suggesting intestinal inflammation may contribute to the disease’s progression. November 2023 -...

New hope in Alzheimer’s through metabolic rescue

Aberrant protein S-nitrosylation in Alzheimer's disease inhibits the TCA cycle, causing synaptic loss due to compromised mitochondrial metabolism. Treatment with dimethyl succinate bypasses this block, partially restoring mitochondrial function and reversing synapse...

Brain health’s link to lymphatic drainage

Using fluorescent tracers in mice, researchers discovered that the nasopharyngeal lymphatic plexus is crucial for draining cerebrospinal fluid (CSF) to deep cervical lymph nodes. Unlike its downstream counterparts, this plexus lacks smooth muscle but has unique valves...

Neuroprotection through dietary restriction and OXR1

OXR1, enhanced by dietary restriction, is key in delaying brain ageing. It supports the retromer, crucial for managing protein and lipid movement, thereby offering neuroprotection and aiding longevity. January 2024 - Nature Communications   Key takeaways  ...

Glial mitochondrial signals impact neuronal proteostasis and ageing

Glial cells, when detecting mitochondrial stress, send signals to neurons that help maintain protein balance and reduce protein aggregation. This communication between glia and neurons is key in regulating protein homeostasis, significantly influencing the aging...

Optimising Alzheimer’s treatment with plaque clearance

A recent article from ALZFORUM reports that complete removal of amyloid plaques, rather than mere reduction, is essential for clinical benefits in Alzheimer's disease treatments. Early amyloid negativity is linked to slowed tangle buildup, emphasizing the importance...

Mitochondrial dysfunction predictive factor for cognitive decline

Mitochondrial dysfunction in skeletal muscles is potentially linked to cognitive impairment and biomarkers of Alzheimer's disease, suggesting a connection between muscle health and brain health in ageing and neurodegeneration. October 2023 - Alzheimer's & Dementia...

ApoE4 influence on Alzheimer’s progression

The ApoE4 gene variant may accelerate tau pathology at lower amyloid levels in Alzheimer's disease, influencing disease progression and treatment strategies​​. November 2023 - JAMA Neurology   Key takeaways   ApoE4 and tau pathology: Individuals carrying the...

Halting ageing: cGAS-STING pathway insights

The cGAS–STING signaling pathway contributes significantly to chronic inflammation and functional deterioration associated with ageing, indicating its potential as a therapeutic target to combat neurodegeneration in later life. August 2023 - Nature   Key...

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