Mitochondrial dysfunction is highlighted as a pivotal element in brain ageing and associated diseases, playing a significant role in energy shortages, elevated oxidative stress, and neuronal harm, driving the advancement of neurodegenerative conditions. March 2024 -...
Gut inflammation associated with ageing and Alzheimer’s risk
Higher gut inflammation levels are linked with ageing and Alzheimer’s disease, with elevated inflammation markers found in older individuals and those with Alzheimer’s, suggesting intestinal inflammation may contribute to the disease’s progression. November 2023 -...
New hope in Alzheimer’s through metabolic rescue
Aberrant protein S-nitrosylation in Alzheimer's disease inhibits the TCA cycle, causing synaptic loss due to compromised mitochondrial metabolism. Treatment with dimethyl succinate bypasses this block, partially restoring mitochondrial function and reversing synapse...
Brain health’s link to lymphatic drainage
Using fluorescent tracers in mice, researchers discovered that the nasopharyngeal lymphatic plexus is crucial for draining cerebrospinal fluid (CSF) to deep cervical lymph nodes. Unlike its downstream counterparts, this plexus lacks smooth muscle but has unique valves...
Neuroprotection through dietary restriction and OXR1
OXR1, enhanced by dietary restriction, is key in delaying brain ageing. It supports the retromer, crucial for managing protein and lipid movement, thereby offering neuroprotection and aiding longevity. January 2024 - Nature Communications Key takeaways ...
Glial mitochondrial signals impact neuronal proteostasis and ageing
Glial cells, when detecting mitochondrial stress, send signals to neurons that help maintain protein balance and reduce protein aggregation. This communication between glia and neurons is key in regulating protein homeostasis, significantly influencing the aging...
Protective effects of apigenin on brain health and cognitive function
Apigenin improves memory and learning in older mice by modulating immune and inflammation-related genes. It also reduces inflammation and cellular ageing in astrocytes, potentially protecting against age-related cognitive decline. November 2023 - Mechanisms of Ageing...
Optimising Alzheimer’s treatment with plaque clearance
A recent article from ALZFORUM reports that complete removal of amyloid plaques, rather than mere reduction, is essential for clinical benefits in Alzheimer's disease treatments. Early amyloid negativity is linked to slowed tangle buildup, emphasizing the importance...
Mitochondrial dysfunction predictive factor for cognitive decline
Mitochondrial dysfunction in skeletal muscles is potentially linked to cognitive impairment and biomarkers of Alzheimer's disease, suggesting a connection between muscle health and brain health in ageing and neurodegeneration. October 2023 - Alzheimer's & Dementia...
ApoE4 influence on Alzheimer’s progression
The ApoE4 gene variant may accelerate tau pathology at lower amyloid levels in Alzheimer's disease, influencing disease progression and treatment strategies. November 2023 - JAMA Neurology Key takeaways ApoE4 and tau pathology: Individuals carrying the...
Have something to add, or want to ask something? Join the conversation in the comments below and we’d be delighted to chat.