Mitochondrial dysfunction is highlighted as a pivotal element in brain ageing and associated diseases, playing a significant role in energy shortages, elevated oxidative stress, and neuronal harm, driving the advancement of neurodegenerative conditions.
March 2024 – Molecular Biology
Key takeaways
- Mitochondrial dysfunction’s role in ageing: The decline in mitochondrial efficiency is a fundamental aspect of the brain’s ageing process, directly influencing the development of neurodegenerative diseases such as Alzheimer’s and Parkinson’s. This dysfunction disrupts cellular energy production, critical for maintaining neuronal health and function
- Energy deficits and neural decline: As mitochondria become less effective, they fail to meet the high energy demands of brain cells, leading to a decrease in cognitive functions and the health of neural networks. This energy shortfall is a key driver behind the deterioration observed in ageing brains, affecting memory, learning, and overall brain performance
- Oxidative stress and neuronal damage: Mitochondrial dysfunction increases the production of reactive oxygen species (ROS), leading to oxidative stress that damages cells. In the brain, this oxidative damage accelerates the loss of neurons and their connections, hastening the decline in cognitive abilities associated with ageing
Addressing mitochondrial dysfunction presents a promising approach to slowing down the brain ageing process and preventing the onset of neurodegenerative diseases. Interventions aimed at enhancing mitochondrial function could improve energy production and reduce oxidative stress, potentially preserving cognitive function and neuronal integrity as we age.
Read the article at: Bartman S, Coppotelli G, Ross JM. Mitochondrial Dysfunction: A Key Player in Brain Aging and Diseases. Mol. Biol. 2024, 46, 1987-2026. https://doi.org/10.3390/cimb46030130