Physical activity significantly lowers the risk of death from all causes and cardiovascular diseases, with women experiencing greater benefits than men, underscoring its importance for longevity, especially in women. February 2024 - Journal of the American College of...
Senescent cells: Targeting with CAR T therapy
Senolytic CAR T cells targeting senescent cells rejuvenate metabolic function in old mice, with a single dose offering long-lasting preventive effects against age-related metabolic dysfunction, highlighting a promising approach for improving healthspan. January 2024 -...
Cell therapy’s impact on heart health
Cell therapy significantly improves the quality of life in patients with ischemic heart failure. This is particularly evident in those with advanced left ventricular enlargement, as measured by the Minnesota Living with Heart Failure Questionnaire. The therapy shows...
Fisetin supplementation for cellular senescence reduction
Fisetin, a natural compound, has been found to improve arterial function in old mice by reducing cellular senescence. This was achieved through intermittent dosing, which led to enhanced endothelial function and decreased arterial stiffness. The improvements were...
Optogenetic stimulation of vagal nerves enhances insulin secretion
Optogenetic stimulation of the vagal nerves enhances insulin secretion and β cell proliferation in response to glucose. This method, involving selective expression of opsins in nerve fibres, shows potential for managing age-related metabolic disorders like diabetes,...
How FOXO3 influences vascular ageing
FOXO3, a gene associated with exceptional human longevity, plays a critical role in regulating vascular ageing and is implicated in various ageing-related vascular diseases. Polymorphisms in FOXO3 are linked to reduced cardiovascular disease morbidity in long-lived...
The promising future of 1,5-AF in age-related diseases
1,5-anhydro-D-fructose (1,5-AF) shows promising anti-ageing effects on brain diseases associated with ageing. It activates AMPK, enhancing the PGC-1α/BDNF pathway. This activation reduces cerebral infarct volume, neurological deficits, and mortality in acute ischemic...
Revitalising aged hearts through metabolic intervention
Suppressing fatty acid oxidation rejuvenates the regenerative capacity of adult mouse hearts, suggesting a potential therapeutic avenue for human heart repair and longevity. September 2023 - Nature Key takeaways Metabolic pathway inhibition: By blocking...
How metabolic rate affects lifespan: gender differences
Scientists conducted a study to understand how the basal metabolic rate (BMR) affects lifespan, specifically considering differences between males and females. BMR refers to the energy the body needs to perform basic functions when at rest. The researchers used a...
Exploring the checkered past of rapamycin: a breakthrough in anti-aging research
This article discusses the interesting story of a drug called rapamycin, which has shown potential as an anti-ageing treatment. Rapamycin was accidentally discovered on Easter Island in the 1970s while scientists were studying soil samples. Originally, it was used as...
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