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Senescent cells: Targeting with CAR T therapy

Senolytic CAR T cells targeting senescent cells rejuvenate metabolic function in old mice, with a single dose offering long-lasting preventive effects against age-related metabolic dysfunction, highlighting a promising approach for improving healthspan. January 2024 -...

Cell therapy’s impact on heart health

Cell therapy significantly improves the quality of life in patients with ischemic heart failure. This is particularly evident in those with advanced left ventricular enlargement, as measured by the Minnesota Living with Heart Failure Questionnaire. The therapy shows...

Fisetin supplementation for cellular senescence reduction

Fisetin, a natural compound, has been found to improve arterial function in old mice by reducing cellular senescence. This was achieved through intermittent dosing, which led to enhanced endothelial function and decreased arterial stiffness. The improvements were...

Optogenetic stimulation of vagal nerves enhances insulin secretion

Optogenetic stimulation of the vagal nerves enhances insulin secretion and β cell proliferation in response to glucose. This method, involving selective expression of opsins in nerve fibres, shows potential for managing age-related metabolic disorders like diabetes,...

How FOXO3 influences vascular ageing

FOXO3, a gene associated with exceptional human longevity, plays a critical role in regulating vascular ageing and is implicated in various ageing-related vascular diseases. Polymorphisms in FOXO3 are linked to reduced cardiovascular disease morbidity in long-lived...

The promising future of 1,5-AF in age-related diseases

1,5-anhydro-D-fructose (1,5-AF) shows promising anti-ageing effects on brain diseases associated with ageing. It activates AMPK, enhancing the PGC-1α/BDNF pathway. This activation reduces cerebral infarct volume, neurological deficits, and mortality in acute ischemic...

Revitalising aged hearts through metabolic intervention

Suppressing fatty acid oxidation rejuvenates the regenerative capacity of adult mouse hearts, suggesting a potential therapeutic avenue for human heart repair and longevity. September 2023 - Nature   Key takeaways   Metabolic pathway inhibition: By blocking...

How metabolic rate affects lifespan: gender differences

Scientists conducted a study to understand how the basal metabolic rate (BMR) affects lifespan, specifically considering differences between males and females. BMR refers to the energy the body needs to perform basic functions when at rest. The researchers used a...

Zoledronic acid: A breakthrough in longevity research

Zoledronic acid, a medication known for reducing fracture risk, has shown potential benefits beyond skeletal health. Some studies indicate that it can decrease mortality in humans and extend both lifespan and health span in animals. These additional effects may be...

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