Vitamin A, via its metabolite all-trans retinoic acid (atRA), controls stem cell differentiation by resolving lineage plasticity. This process is essential for proper tissue repair and maintaining correct cell lineages in the skin, including hair follicles and...
Reversing ageing in blood stem cells
Epigenetic changes in ageing hematopoietic stem cells are linked to hematologic disorders, highlighting the importance of DNA methylation and histone modifications. December 2023 - Epigenomes Key takeaways Ageing in hematopoietic stem cells: The natural...
HiPS cells and the future of epigenetic reprogramming
Transient naive reprogramming is a new method for creating human induced pluripotent stem cells (hiPS cells) from somatic cells, resulting in cells with epigenetic and functional characteristics remarkably similar to human embryonic stem cells. This technique...
Exosomes: A breakthrough in joint ageing
Human umbilical cord mesenchymal stem cells (hUC-MSCs) release exosomes that have anti-inflammatory effects on osteoarthritis-affected chondrocytes, potentially offering a novel treatment for arthritis-related joint degeneration and contributing to longevity by...
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