Mitochondrial dysfunction is highlighted as a pivotal element in brain ageing and associated diseases, playing a significant role in energy shortages, elevated oxidative stress, and neuronal harm, driving the advancement of neurodegenerative conditions. March 2024 -...
Fighting memory loss with KIBRA
KIBRA improves brain connectivity and memory, providing defense against memory decline linked to tauopathy, prevalent in neurodegenerative conditions. February 2024 - Journal of Clinical Investigation Key takeaways Enhanced synaptic plasticity: KIBRA...
Hypothalamic neurons: Key to longer life?
DMHPpp1r17 neurons in the mouse hypothalamus play a crucial role in regulating ageing and lifespan. They influence physical activity and white adipose tissue function, impacting the ageing process. Modifying these neurons' activity can alleviate age-related decline...
Protective effects of apigenin on brain health and cognitive function
Apigenin improves memory and learning in older mice by modulating immune and inflammation-related genes. It also reduces inflammation and cellular ageing in astrocytes, potentially protecting against age-related cognitive decline. November 2023 - Mechanisms of Ageing...
The promising future of 1,5-AF in age-related diseases
1,5-anhydro-D-fructose (1,5-AF) shows promising anti-ageing effects on brain diseases associated with ageing. It activates AMPK, enhancing the PGC-1α/BDNF pathway. This activation reduces cerebral infarct volume, neurological deficits, and mortality in acute ischemic...
Breathing’s role in memory and ageing
Breathing not only sustains life but also significantly impacts memory. Controlled breathing during memory formation can sharpen cognitive functions, suggesting a potential strategy for enhancing memory performance and contributing to healthier ageing. July 2023 -...
Enhancing brain health through HMB
HMB, a muscle-building supplement, binds to PPARα, enhancing hippocampal functions and reducing Alzheimer’s disease plaques in mice. This interaction highlights HMB's potential as a neuroprotective agent, opening avenues for its use in combating cognitive decline and...
The brain’s protein puzzle: ageing and memory
Cognitive decline with age is linked to reduced S-nitrosylated proteins in the brain. The protein CaMKII, essential for learning and memory, requires S-nitrosylation for optimal function. Young mice lacking this S-nitrosylation in CaMKII exhibited cognitive...
Superagers’ secrets to preserving memory with age
Superagers, individuals who age without significant memory decline, possess unique brain structures and lifestyles. This study reveals that superagers have higher grey matter volume in specific brain regions and slower brain atrophy. Notably, faster movement speed and...
Linking dental health to brain ageing
Exploring the intriguing link between dental health and hippocampal atrophy, this study reveals that in older adults, fewer teeth correlate with faster left hippocampal atrophy in mild periodontitis cases, while more teeth correlate with faster atrophy in severe...
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