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Hypothalamic neurons: Key to longer life?

DMHPpp1r17 neurons in the mouse hypothalamus play a crucial role in regulating ageing and lifespan. They influence physical activity and white adipose tissue function, impacting the ageing process. Modifying these neurons' activity can alleviate age-related decline...

The promising future of 1,5-AF in age-related diseases

1,5-anhydro-D-fructose (1,5-AF) shows promising anti-ageing effects on brain diseases associated with ageing. It activates AMPK, enhancing the PGC-1α/BDNF pathway. This activation reduces cerebral infarct volume, neurological deficits, and mortality in acute ischemic...

Breathing’s role in memory and ageing

Breathing not only sustains life but also significantly impacts memory. Controlled breathing during memory formation can sharpen cognitive functions, suggesting a potential strategy for enhancing memory performance and contributing to healthier ageing. July 2023 -...

Enhancing brain health through HMB

HMB, a muscle-building supplement, binds to PPARα, enhancing hippocampal functions and reducing Alzheimer’s disease plaques in mice. This interaction highlights HMB's potential as a neuroprotective agent, opening avenues for its use in combating cognitive decline and...

The brain’s protein puzzle: ageing and memory

Cognitive decline with age is linked to reduced S-nitrosylated proteins in the brain. The protein CaMKII, essential for learning and memory, requires S-nitrosylation for optimal function. Young mice lacking this S-nitrosylation in CaMKII exhibited cognitive...

Superagers’ secrets to preserving memory with age

Superagers, individuals who age without significant memory decline, possess unique brain structures and lifestyles. This study reveals that superagers have higher grey matter volume in specific brain regions and slower brain atrophy. Notably, faster movement speed and...

Linking dental health to brain ageing

Exploring the intriguing link between dental health and hippocampal atrophy, this study reveals that in older adults, fewer teeth correlate with faster left hippocampal atrophy in mild periodontitis cases, while more teeth correlate with faster atrophy in severe...

How stress affects ageing: Insights from a new study

New research reveals that physiological stress load may accelerate ageing by affecting immune cells. The study found that stress load correlates with age and is linked to changes in T lymphocyte subsets, which are crucial for immune response. This suggests that...

Vibrotactile stimulation: Boosting brain health and motor skills

A recent study explored the effects of a type of sensory stimulation called vibrotactile stimulation on brain health and motor skills. The researchers found that this type of stimulation, which involves gentle vibrations at a specific frequency, can help reduce the...

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