A new molecular index based on blood metabolites can measure biological age, which may reflect health better than chronological age. This index helps distinguish between individuals ageing at different rates and suggests that lifestyle changes could potentially...
Biological age influences epigenetic ageing in human blood cells
Epigenetic ageing of human blood cells corresponds with the biological age of the individual, indicating that blood cells age in sync with the body's overall ageing process. March 2024 - Aging Cell Key takeaways Epigenetic ageing in human blood cells...
Slowing ageing with senolytics
Senolytic drugs dasatinib, quercetin, and fisetin may influence longevity and age-related decline by affecting DNA methylation clocks. February 2024 - Aging Key takeaways Dasatinib, quercetin, and fisetin's impact on ageing: These compounds may influence...
Reversing age with stress recovery
Biological age is dynamic and can rapidly change in response to stress, as observed in young mice and humans. Stress increases biological age, but this effect can be reversed upon recovery. This phenomenon is evident at epigenetic, transcriptomic, and metabolomic...
New DNA clock measures mammalian ageing
A universal DNA methylation-based clock accurately estimates age across different mammalian tissues, aiding ageing research and the pursuit of longevity interventions. August 2023 - Nature Aging Key takeaways Refined accuracy of universal DNA methylation clock:...
Redefining age: Insights from the PCAge clock
The PCAge clinical ageing clock identifies healthy and unhealthy ageing patterns. Using ACE-Is or ARBs reduces mortality risk and slows biological age acceleration, offering a proactive approach to ageing and age-related diseases. Key takeaways: The principal...
How excess weight fast-forwards your biological clock
Being overweight is causally linked to accelerated ageing, evidenced by shorter telomeres, increased frailty, and more pronounced facial ageing. These findings highlight the significance of weight management in countering the effects of rapid ageing. Key...
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