Research - Melbourne Functional Medicine

The impact of TRP channel inhibition on longevity

09.12.2024

Aminoglycoside antibiotics, such as streptomycin, can inhibit TRP channels, disrupting calcium signalling essential for muscle and adipose tissue development. This interference may impair metabolic balance, potentially affecting healthspan and longevity.

Fitness and movement Functional medicine Longevity and ageing

Boosting longevity with Ellagitannins and Urolithin A

07.12.2024

Researchers have identified a specific gut bacterium that produces urolithin A, a compound linked to improved muscle function and increased lifespan. This discovery suggests that enhancing the presence of this bacterium could be a potential strategy for promoting healthy ageing.

Detoxification and gut health Longevity and ageing Nutrition and diet

Microplastics found in the brain and their impact on ageing

03.12.2024

Researchers detected microplastics in human brain tissue using pyrolysis gas chromatography-mass spectrometry, indicating potential bioaccumulation. This finding raises concerns about microplastics' impact on neurological health and ageing.

Brain health Detoxification and gut health Longevity and ageing

Dietary acid reduction as a pathway to healthy ageing

30.11.2024

Reducing dietary acid through increased intake of fruits and vegetables or sodium bicarbonate supplementation slows chronic kidney disease progression, lowers systolic blood pressure, and improves cardiovascular health.

Functional medicine Longevity and ageing Nutrition and diet

The role of mTORC1/2 in safeguarding ovarian function

23.11.2024

Inhibiting mTORC1/2 during chemotherapy helps preserve ovarian function and fertility in mice, offering a potential approach to reducing chemotherapy-induced reproductive ageing and supporting healthspan.

Biohacking and optimisation Hormonal and immune health Longevity and ageing

Preserving cognitive function through improved lymphatic drainage

20.11.2024

Restoring cervical lymphatic vessel function in ageing improves brain drainage, reduces inflammation, and enhances cognitive function. This approach could counter age-related cognitive decline, supporting healthier ageing and potentially extending healthspan.

Brain health Functional medicine Longevity and ageing

A humanised mouse model reveals pathways to enhance longevity

19.11.2024

A humanised mouse model now produces mature, class-switched, and hypermutated antibodies, offering insights into immune responses and advancing vaccine and antibody therapy research. This model may accelerate immunity understanding, supporting healthspan and longevity research.

Advanced testing Hormonal and immune health Longevity and ageing

Slowing brain ageing through region-specific Alzheimer’s insights

15.11.2024

Single-cell analysis maps Alzheimer’s progression across brain regions, revealing specific cellular and molecular changes. The findings suggest targeted interventions could address Alzheimer's-related dysfunction, potentially slowing progression and preserving brain health.

Brain health Genetics and epigenetics Longevity and ageing

Uridine’s role in rejuvenating ageing blood stem cells and boosting healthspan

14.11.2024

Uridine rejuvenates aged hematopoietic stem cells in mice, enhancing blood cell function and countering age-related stem cell decline—an essential factor for promoting healthspan and longevity.