SCIENTIFIC RESEARCH
Trending insights on health and longevity
Our clinical team spends considerable time reading the latest research in the field of ageing and longevity. Because scientific papers can take time to digest, we’ve done the work for you. Search our database of summarised research below.
MYCT1 gene discovery reveals key to blood stem cell renewal and longevity
MYCT1 is essential for how human hematopoietic stem cells (HSCs) sense and respond to their environment, which is crucial for their self-renewal and long-term function. This discovery points to potential therapies that could maintain healthy blood...
Mitochondrial disposal in ageing heart tissues and its impact on longevity
When lysosomal function is impaired, cells release dysfunctional mitochondria through large extracellular vesicles instead of breaking them down. This process occurs independently of autophagy, helps preserve cellular health, and is observed in...
Human cells create self-healing biobots for regenerative medicine and ageing
Anthrobots are motile biobots made from adult human lung cells, showcasing the plasticity of human tissues. These spheroid-shaped biobots, driven by cilia, demonstrate varied movement patterns and can repair damaged tissues, presenting new...
Life’s essential 8 slows biological ageing and reduces cardiovascular risk
Adhering to "Life's Essential 8" is associated with reduced cardiovascular disease and mortality, primarily through a younger epigenetic age, underscoring the importance of lifestyle in slowing biological ageing and promoting longevity. May 2024 -...
Cardiorespiratory fitness: A key predictor of lifespan and healthspan
Higher cardiorespiratory fitness (CRF) significantly reduces the risk of chronic diseases and death. Involving 20.9 million participants from 199 studies, this analysis highlights CRF's crucial role in enhancing healthspan and longevity. May 2024 -...
Rejuvenating aged stem cells to extend health and lifespan
Key strategies to rejuvenate aged stem cells and extend healthspan and lifespan include physical exercise, diet manipulation, targeting senescence, autophagy, epigenetic reprogramming, and using circulating blood factors. These methods enhance...
Reversing muscle ageing with heavy resistance training
Human skeletal muscle ageing features irregular myofiber shapes, especially in type II fibres, leading to reduced muscle function and mass. Heavy resistance training can reverse these changes, improving muscle health in the elderly. February 2024 -...
Efficient DNA-protein crosslink repair enhances longevity
Endogenous aldehyde-induced DNA-protein crosslinks (DPCs) are efficiently resolved by transcription-coupled repair (TCR), protecting against metabolic genotoxins. This process explains the molecular pathogenesis of diseases like AMeDS and Cockayne...
Mitochondrial H2O2 and its indirect role in ageing
Mitochondrial H2O2 release doesn't directly damage chromosomal DNA but influences ageing through signalling pathways, offering potential targets for anti-ageing interventions. March 2024 - Antioxidants Key takeaways Mitochondrial H2O2...
Antioxidants combat age-related diseases by reducing oxidative stress
Antioxidants combat age-related diseases by reducing oxidative stress, potentially enhancing longevity and healthspan. Dietary intake and supplements are highlighted as effective strategies for promoting healthy ageing. October 2022 - Biomedicines...
