Ageing undergoes two key periods of rapid change: early adulthood and later life. These transitions significantly impact health and biological ageing, offering opportunities to target interventions and optimise healthspan during these critical phases.
The impact of TRP channel inhibition on longevity
Aminoglycoside antibiotics, such as streptomycin, can inhibit TRP channels, disrupting calcium signalling essential for muscle and adipose tissue development. This interference may impair metabolic balance, potentially affecting healthspan and longevity.
Geographic variation in life expectancy across Anglophone nations
Australia leads in life expectancy among high-income Anglophone nations, outperforming in reducing premature mortality from cardiovascular, respiratory, and external causes. It also exhibits lower geographic inequality in mortality, while the USA lags significantly, highlighting disparities and the importance of effective health policies for ageing populations.
Oxidative stress and inflammation: The hidden culprits behind cholesterol’s bad reputation
Cholesterol isn’t the villain it’s made out to be. Learn how oxidative stress and inflammation – not cholesterol itself – are the real culprits behind cardiovascular risks. Discover practical strategies like better hydration, diverse nutrition, and stress management to optimise your health and rethink the cholesterol narrative.
Dietary acid reduction as a pathway to healthy ageing
Reducing dietary acid through increased intake of fruits and vegetables or sodium bicarbonate supplementation slows chronic kidney disease progression, lowers systolic blood pressure, and improves cardiovascular health.
Healthspan vs lifespan: What’s the difference?
Discover the difference between living long and living well! Mark’s blog dives into healthspan vs lifespan, explains why biological age matters, and shares how small, impactful lifestyle changes can help you stay healthier for longer.
Preserving cognitive function through improved lymphatic drainage
Restoring cervical lymphatic vessel function in ageing improves brain drainage, reduces inflammation, and enhances cognitive function. This approach could counter age-related cognitive decline, supporting healthier ageing and potentially extending healthspan.
The impact of hydrogen peroxide on cellular stress and longevity
Mitochondrial hydrogen peroxide (H2O2) doesn’t directly harm chromosomal DNA but plays a role in redox signalling, which helps regulate cellular responses to oxidative stress. This suggests that H2O2 has a more complex function in ageing, highlighting potential therapeutic strategies to reduce oxidative damage while maintaining its beneficial signalling effects.
What is Medicine 3.0? Your guide to finding it in Australia
Medicine 3.0 is a proactive, personalised and preventative approach to healthcare, focusing on optimising healthspan. At Melbourne Functional Medicine, we apply Medicine 3.0 principles through functional medicine, helping patients achieve optimal health and longevity.
Stem cell-derived islet tissues offer insulin independence
Autologous stem cell-derived islet tissues restored insulin function in a type 2 diabetes patient, achieving glycemic control, insulin independence, and no tumor formation over 116 weeks.