Changes in gut bacteria in Parkinson’s disease are associated with lower production of key nutrients and anti-inflammatory compounds, suggesting gut-targeted strategies may help support brain health and slow disease progression.
Hormesis: Using controlled stress to go harder, faster, stronger, smarter
Discover how small, controlled stressors like fasting, heat, cold, and low-oxygen training can trigger powerful adaptations in the body. Hormesis helps boost resilience, improve performance, sharpen cognition, and support healthy ageing – when done in the right dose.
Optimise your oral microbiome: Habits, products, breathing and more
Your oral microbiome does far more than protect your teeth – it influences immunity, inflammation, and whole-body health. Learn how to optimise it through smarter habits, better product choices, nasal breathing, and targeted strategies to reshape this vital ecosystem.
Restoring the brain’s sugar shield boosts memory
Ageing disrupts a key sugar-protein layer called the glycocalyx lining brain blood vessels, weakening the blood–brain barrier and increasing brain inflammation and cognitive decline; restoring this layer in mice improves brain health and memory.
Autophagy, mitochondria and mTOR: sulforaphane’s secret to healthy ageing
Sulforaphane triggers fasting-like responses in human cells, enhancing mitochondrial function, autophagy, and nutrient-sensing pathways, while suppressing glucose uptake and mTOR signalling—mimicking the benefits of caloric restriction.
Why midlife is the sweet spot for heart health
Structured high- and moderate-intensity exercise over two years reversed heart stiffening in previously sedentary middle-aged adults, improving cardiovascular fitness and potentially reducing future heart failure risk, showing it’s never too late to start exercising.
Cancer cells hijack immune mitochondria and disarm tumour defences
Cancer cells transfer damaged mitochondria into immune cells, causing dysfunction and early ageing in T cells, weakening the body’s natural defence against tumours.
How ageing drives cancer across the lifespan
Aging and cancer are deeply interconnected, influencing one another across the lifespan through immune decline, tissue changes, and cumulative environmental exposures, urging age-tailored approaches to cancer prevention, treatment, and research.
High-dose vitamin D boosts muscle over fat
High-dose vitamin D redirects surplus calories towards muscle growth and away from fat storage by modulating myostatin and leptin signalling. This promotes lean mass, strength, and linear growth without increasing overall weight, offering a new framework for enhancing body composition, energy balance, and metabolic health across the lifespan.
Living higher, ageing slower: the altitude effect
Higher altitude living in Ethiopia is linked to lower disease burden, reduced DNA damage-related senescence, and longer life expectancy, despite signs of increased facial ageing from UV exposure.