Intermittent senolytic therapy with dasatinib and quercetin showed no significant decrease in bone resorption in postmenopausal women overall.
Targeting Tregs to extend healthspan and delay the effects of ageing
Regulatory T cells (Tregs) help prevent stem cell exhaustion, a key factor in ageing. As Treg function declines with age, immune imbalance occurs, accelerating the ageing process. This contributes to various age-related diseases. Therapeutically targeting Tregs could slow immuno-ageing, promoting longevity and better health outcomes.
Cellular senescence and its impact on metabolic ageing
Cellular senescence, where cells stop dividing but remain metabolically active, leads to the release of harmful molecules that drive ageing and metabolic dysfunction. Addressing the metabolic changes in senescent cells could help reduce ageing effects and related diseases.
Microplastics detected in human seminal fluid: Potential health risks
Microplastics were detected in human seminal fluid, raising concerns about their impact on male reproductive health and potential long-term effects on fertility and ageing. This study used Raman spectroscopy to highlight the prevalence of microplastic contamination in a sample of the general male population.
MYCT1 gene discovery reveals key to blood stem cell renewal and longevity
MYCT1 is essential for how human hematopoietic stem cells (HSCs) sense and respond to their environment, which is crucial for their self-renewal and long-term function. This discovery points to potential therapies that could maintain healthy blood stem cells, support immune function, and enhance longevity by preserving stem cell regenerative abilities.
Cold exposure – the science
Done correctly, deliberate cold exposure including cold showers, ice baths, cold water immersion and cryotherapy can positively affect brain and body health. But how cold should the water be and how long do you need to stay exposed for it to be effective? And what are the benefits of this this type of hormetic stress?
IgG linked to ageing and metabolic decline
Immunoglobulin G (IgG) accelerates ageing by causing fibrosis in fat tissue, which leads to a decline in metabolic health, highlighting potential targets for anti-ageing treatments. February 2024 - Cell Metabolism Key takeaways Immunoglobulin G (IgG) and...
LED irradiation: A breakthrough in otitis media treatment
Red and near-infrared LED irradiation shows promise in treating otitis media (OM), a middle ear inflammatory condition. By applying this treatment in a rat model and cell lines, researchers observed a significant reduction in ear mucosal thickness, inflammatory cells,...
Breakthrough in cancer treatment: Molecular jackhammers
Molecular jackhammers activate vibronic modes in single molecules, efficiently destroying cancer cells by mechanically disassembling their membranes, offering a potential alternative to traditional cancer therapies with fewer side effects. December 2023 - Nature...
Decoding your DNA: A personalised blueprint to optimise your health
Explore the transformative power of DNA testing for personalised health in this comprehensive guide. Learn how understanding your genetic blueprint can optimise your health, tailor your lifestyle, and enhance your wellbeing for a better, healthier life.