Benzyl butyl phthalate (BBP) exposure damages DNA and accelerates ageing

Benzyl butyl phthalate (BBP), a common plasticiser, disrupts reproductive health by increasing DNA damage and oxidative stress. Exposure impairs chromosome stability and gene expression, potentially affecting fertility and ageing. Findings highlight concerns about environmental toxins’ impact on longevity and underscore the need for minimising exposure.

Genetic variability and the effects of dietary restriction on lifespan

Caloric restriction (20%-40%) and intermittent fasting enhanced lifespan in genetically diverse mice, with stronger effects tied to stricter calorie reduction. Lifespan varied with genetics and stress resilience, revealing healthspan and longevity are not always aligned. Extreme restrictions caused adverse effects, questioning optimal dietary strategies for ageing.

Mitochondria therapy improves stromal cell function and longevity

Artificial mitochondrial transplantation rejuvenates mesenchymal stromal cells, reducing senescence and enhancing anti-inflammatory effects. By transferring healthy mitochondria, aged cells regain energy metabolism, diminish oxidative stress, and improve insulin sensitivity, presenting a promising tool for regenerative therapies targeting ageing and chronic inflammation.

The role of mTORC1/2 in safeguarding ovarian function

Inhibiting mTORC1/2 during chemotherapy helps preserve ovarian function and fertility in mice, offering a potential approach to reducing chemotherapy-induced reproductive ageing and supporting healthspan.

A humanised mouse model reveals pathways to enhance longevity

A humanised mouse model now produces mature, class-switched, and hypermutated antibodies, offering insights into immune responses and advancing vaccine and antibody therapy research. This model may accelerate immunity understanding, supporting healthspan and longevity research.

Blocking IL-11 to extend lifespan and reduce frailty in ageing

Blocking IL-11, a pro-inflammatory protein, extended lifespan and improved health in mice, reducing frailty and metabolic decline. Inhibiting IL-11 led to a lifespan increase of up to 25%, showing promise as a therapeutic target for enhancing human healthspan.​

Targeting Tregs to extend healthspan and delay the effects of ageing

Regulatory T cells (Tregs) help prevent stem cell exhaustion, a key factor in ageing. As Treg function declines with age, immune imbalance occurs, accelerating the ageing process. This contributes to various age-related diseases. Therapeutically targeting Tregs could slow immuno-ageing, promoting longevity and better health outcomes.

Cellular senescence and its impact on metabolic ageing

Cellular senescence, where cells stop dividing but remain metabolically active, leads to the release of harmful molecules that drive ageing and metabolic dysfunction. Addressing the metabolic changes in senescent cells could help reduce ageing effects and related diseases.