Immunoglobulin G (IgG) accelerates ageing by causing fibrosis in fat tissue, which leads to a decline in metabolic health, highlighting potential targets for anti-ageing treatments.
February 2024 – Cell Metabolism
Key takeaways
- Immunoglobulin G (IgG) and ageing: IgG, a type of antibody, has been identified as a significant factor that accelerates ageing. Its role extends beyond the immune response, implicating it in the ageing process at a molecular level
- IgG-induced fibrosis in adipose tissue: IgG contributes to the development of fibrosis in adipose (fat) tissue. This fibrosis, or thickening and scarring of connective tissue, disrupts normal fat tissue function and metabolism, leading to detrimental effects on health
- Metabolic decline linked to IgG: The effect of IgG on adipose tissue fibrosis directly correlates with a decline in metabolic health. As metabolism slows down, the body becomes less efficient at converting food into energy, leading to various age-related diseases and conditions
- Anti-ageing therapeutic potential: The discovery of IgG’s role in ageing and metabolism opens up new opportunities for targeting these mechanisms in anti-ageing therapies. By potentially modulating or inhibiting IgG’s harmful effects, it may be possible to develop treatments that improve longevity and healthspan
Read the article at: Yu, Lexiang, et al. Immunoglobulin G (IgG) is an aging factor that drives adipose tissue fibrosis and metabolic decline. Cell Metabolism, vol. 19, no. 3, 2014, pp. 409-425
