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Gut inflammation associated with ageing and Alzheimer’s risk

Feb 12, 2024

Higher gut inflammation levels are linked with ageing and Alzheimer’s disease, with elevated inflammation markers found in older individuals and those with Alzheimer’s, suggesting intestinal inflammation may contribute to the disease’s progression.

November 2023 – Scientific Reports


Key takeaways


  • Gut inflammation and ageing: The body’s gut inflammation levels rise naturally with age. This increase in inflammation is a significant factor that contributes to the ageing process, indicating that maintaining gut health could be essential for promoting longevity
  • Fecal calprotectin and Alzheimer’s Disease: Elevated fecal calprotectin, which signals intestinal inflammation, is directly associated with an increased amyloid burden within the brain. This connection highlights the importance of monitoring and managing gut inflammation as a potential approach to prevent or slow down the development of Alzheimer’s disease
  • Intestinal inflammation and brain pathology: The study suggests that intestinal inflammation is not just a consequence but may play a role in initiating brain pathology characteristic of Alzheimer’s disease. This implies that interventions aimed at reducing gut inflammation could have a protective effect on brain health, even before Alzheimer’s symptoms become apparent


The findings highlight the potential of gut health management as a strategy for ageing healthily and reducing the risk of Alzheimer’s disease. This could involve dietary changes, probiotics, and lifestyle adjustments aimed at maintaining a healthy microbiome and reducing inflammation levels.


Read the article at: Heston, M.B., Hanslik, K.L., Zarbock, K.R. et al. Gut inflammation associated with age and Alzheimer’s disease pathology: a human cohort study. Sci Rep 13, 18924 (2023).