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Senescence markers reduced in skin

Aug 6, 2023

A senotherapeutic peptide significantly reduces biological age and cellular senescence in human skin, indicating a potential breakthrough in anti-ageing treatments.

May 2023 – npj Aging


Key takeaways


  • Rejuvenation of aged skin: The peptide treatment rejuvenates aged human skin, suggesting a reversal of age-related changes and a restoration of youthful skin function
  • Reduction of senescence markers: Treatment leads to a significant decrease in senescence markers, indicating a potential slowdown in the ageing process at the cellular level
  • DNA methylation age lowered: The treatment modifies DNA methylation patterns, effectively reducing the biological age of skin cells, which is a key indicator of cellular ageing
  • Younger skin structure and molecular profile: Post-treatment, the skin exhibits structural and molecular characteristics similar to younger skin, implying a restoration of skin integrity and health


It’s fascinating to see how a single peptide can play a role in turning back the clock on our skin’s biological age. The implications of reducing senescence markers and tweaking DNA methylation patterns are profound, not just for the appearance of our skin but potentially for the health of our entire body. This study opens up a dialogue about the future of longevity and how we might harness these kinds of discoveries for overall health optimisation.


If we can rejuvenate the skin, might we also be able to apply similar principles to other tissues and organs? Could this be a stepping stone towards a future where ageing is not just slowed but perhaps partially reversed?


Read the article at: Zonari, A., Brace, L.E., Al-Katib, K. et al. Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models. npj Aging 9, 10 (2023).