The mTOR signaling pathway is crucial for cell growth and metabolism, affecting aging and disease. Properly regulating mTOR could treat age-related conditions and potentially extend lifespan, but careful modulation is essential to prevent negative side effects.
October 2023 – Signal Transduction and Targeted Therapy
- mTOR pathway and longevity: The mTOR pathway’s role in cell growth and metabolism suggests that its careful regulation is key to slowing down the ageing process and promoting increased lifespan
- Pharmacological targeting of mTOR: Drugs like rapamycin that target the mTOR pathway show promise in extending the period of life free from age-related diseases, indicating a potential pharmacological route to enhance longevity
- Risks of overactive mTOR signaling: Excessive activity of the mTOR pathway is associated with accelerated cellular ageing and a higher incidence of age-related diseases, emphasising the need for precise control of this pathway
- Importance of mTOR balance: While mTOR inhibition has benefits, it’s crucial to maintain a balance since the pathway also supports essential cellular functions. Over-inhibition could disrupt these processes and lead to negative health outcomes
Read the article at: Panwar, V., Singh, A., Bhatt, M. et al. Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease. Sig Transduct Target Ther 8, 375 (2023). https://doi.org/10.1038/s41392-023-01608-z