Anthrobots are motile biobots made from adult human lung cells, showcasing the plasticity of human tissues. These spheroid-shaped biobots, driven by cilia, demonstrate varied movement patterns and can repair damaged tissues, presenting new possibilities in regenerative medicine and bioengineering.
November 2023 – Advanced Science
Key Takeaways
- Self-organisation and tissue regeneration potential: Anthrobots illustrate the remarkable ability of adult human cells to self-organise into complex, functional structures without the need for genetic modification or external scaffolding. This suggests that the inherent plasticity of human tissues can be harnessed to create new, self-repairing systems. For those focused on longevity, this indicates a pathway to developing regenerative therapies that can repair or replace ageing tissues, potentially slowing down or reversing age-related decline
- Cilia-driven movement and enhanced cellular motility: The use of cilia-driven propulsion in Anthrobots highlights a natural mechanism by which cellular structures can achieve autonomous movement. This finding is significant because it offers insights into how we might enhance cellular motility in therapeutic contexts. Improved cellular movement could facilitate more effective tissue repair and regeneration, which is crucial for maintaining tissue function and integrity as the body ages
- Tissue repair in damaged environments: The ability of Anthrobots to induce rapid repair of damaged tissues, such as neuronal monolayers, showcases their potential as a tool for addressing age-related tissue degeneration. As tissues become more prone to damage and slower to repair with age, technologies that can expedite the healing process are invaluable. This capability points toward new strategies for maintaining tissue health and functionality in ageing populations, potentially extending healthspan
The discovery that adult human cells can be coaxed into forming entirely new functional structures highlights the untapped potential within our own cells for regenerative medicine. For those interested in longevity, this opens up exciting possibilities for using the body’s existing cellular machinery to create therapies that promote tissue rejuvenation, combat age-related diseases, and ultimately, extend both lifespan and healthspan.
Read the article at: Gumuskaya, Gizem, et al. “Motile Living Biobots Self‐Construct from Adult Human Somatic Progenitor Seed Cells.” Advanced Science, vol. 11, 2023, pp. 1-20. Wiley-VCH GmbH. DOI: 10.1002/advs.202303575