SIRT6 regulates DNA repair and metabolic pathways, extending lifespan in mice by stabilising chromatin structure and preventing age-related diseases. This highlights potential therapeutic strategies for improving healthspan and longevity.
August 2024 – Cell Metabolism
Key Takeaways
- SIRT6 boosts DNA repair efficiency: Enhanced DNA repair helps maintain genome integrity, reducing the accumulation of damage over time. This slows the onset of age-related diseases and is linked to extended lifespan, making DNA stability a key factor in promoting healthy ageing and longevity
- Chromatin structure stability prevents ageing: By stabilising chromatin, SIRT6 protects cells from harmful changes associated with ageing. This preservation of chromatin structure reduces the risk of developing degenerative diseases and keeps cellular functions more efficient throughout the ageing process
- SIRT6 regulates critical metabolic pathways: Regulating metabolic pathways helps maintain energy balance and cellular function. SIRT6’s role in metabolism links it to slowing the ageing process, as healthier metabolic activity is essential for overall longevity and reducing the effects of age-related health decline
SIRT6 presents a promising therapeutic target to enhance healthspan and reduce ageing effects. By focusing on SIRT6 activation, it’s possible to develop treatments that address age-related damage and metabolic dysfunction, potentially increasing both lifespan and quality of life.
Read article at: Roichman, Amit, et al. “SIRT6 enhances longevity through chromatin-based mechanisms.” Cell Reports, vol. 42, no. 12, 2024, DOI: 10.1016/j.celrep.2024.112419.