Uridine rejuvenates aged hematopoietic stem cells in mice, enhancing blood cell function and countering age-related stem cell decline—an essential factor for promoting healthspan and longevity.
July 2024 – Nature Aging
Key Takeaways
- Uridine revitalises aged blood stem cells, improving their function and resilience: Uridine, a natural metabolite, has been shown to reinvigorate aged hematopoietic stem cells, restoring their functional capabilities. This boost in stem cell vitality helps maintain the regenerative potential of the blood, supporting resilience against age-related cellular wear
- Enhanced blood cell activity supports overall health and reduces age-related cellular decline: By enhancing blood cell function, uridine helps combat the decline in cell performance associated with ageing. This improvement in cellular activity strengthens the immune system and promotes healthier tissue maintenance, contributing to a healthier lifespan
- Uridine offers a potential intervention for counteracting ageing in blood and immune systems: The ability of uridine to rejuvenate ageing blood cells highlights its promise as a therapeutic tool for the ageing population. By targeting age-associated changes in blood and immune cells, uridine could be key in slowing the deterioration of these essential systems
Stem cells are fundamental to tissue repair and regeneration. Protecting and enhancing their health, especially as we age, is vital for preserving bodily functions over the long term. Supporting stem cell function with interventions like uridine could significantly extend healthy years.
Read article at: Martín-García, Rafael, et al. “A metabolic atlas of blood cells in young and aged mice identifies uridine as a metabolite to rejuvenate aged hematopoietic stem cells.” Nature Aging, 2024, doi:10.1038/s43587-024-00669-1.