OSKM gene therapy in the hippocampus rejuvenates cognitive function in aged rats, improving spatial memory and cognitive abilities without harmful effects. The treatment reverses age-related DNA methylation changes, suggesting potential for brain rejuvenation and delaying cognitive decline.
July 2024 – Springer Nature Link
Key Takeaways
- Enhanced Cognitive Function with OSKM Gene Therapy: OSKM gene therapy directly in the hippocampus significantly rejuvenates cognitive abilities in aged brains, specifically enhancing spatial memory, a crucial component of daily cognitive function in ageing
- Reversal of Age-Related DNA Methylation: This treatment effectively reverses age-related changes in DNA methylation patterns within the hippocampus, a marker often associated with cognitive ageing, suggesting a regenerative impact on brain health
- No Adverse Side Effects Observed: OSKM gene therapy produced these cognitive benefits without triggering harmful side effects, indicating its safety and potential suitability for long-term cognitive support
The therapy shows promising potential to delay or mitigate age-related cognitive decline, offering a new avenue for preserving brain function and promoting longevity.
Read the article at: Klein, Iris, et al. “Cognitive Rejuvenation in Old Rats by Hippocampal OSKM Gene Therapy.” GeroScience, 2024, doi:10.1007/s11357-024-01269-y.