Regulatory T cells (Tregs) help prevent stem cell exhaustion, a key factor in ageing. As Treg function declines with age, immune imbalance occurs, accelerating the ageing process. This contributes to various age-related diseases. Therapeutically targeting Tregs could slow immuno-ageing, promoting longevity and better health outcomes.
July 2024 – Cell Press
Key Takeaways
- Regulatory T cells (Tregs) help prevent stem cell exhaustion, which is crucial for healthy ageing: Tregs play a protective role by maintaining the functionality of stem cells, which are vital for tissue repair and regeneration. Preventing stem cell exhaustion ensures that the body can continue to repair itself, slowing down the physical decline associated with ageing
- Treg function declines with age, leading to immune imbalance and faster ageing: As we age, the efficiency of Tregs decreases, which results in a weakened immune system. This imbalance accelerates the ageing process, leaving the body more vulnerable to infections and diseases
- This immune decline contributes to age-related diseases and reduced lifespan: Diminished Treg function increases susceptibility to chronic conditions such as cardiovascular diseases, neurodegenerative disorders, and other age-related illnesses, ultimately shortening lifespan and compromising quality of life
By developing treatments that enhance or preserve Treg activity, it may be possible to slow down the ageing process, extend healthspan, and reduce the prevalence of age-associated diseases, leading to a longer, healthier life.
Read the article at: Takahashi, Shuichiro, et al. “Regulatory T Cells and Stem Cell Exhaustion in Immuno-Ageing.” Immunity, vol. 57, no. 3, 2024, pp. 354-370. Cell Press, https://doi.org/10.1016/j.immuni.2024.05.017.